DC/CIK细胞治疗152例肿瘤的副反应观察  被引量:2

Observation of side effects of cancer patients receiving DC/CIK cell therapy in 152 cases

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作  者:安东建[1] 柴琴[1] 田垣[1] 龚奎玉[1] 苏天海[1] 汤效[1] 谭小浪[1] 王伟明[1] 

机构地区:[1]长沙市中心医院肿瘤科,湖南长沙410004

出  处:《中国当代医药》2013年第1期6-8,共3页China Modern Medicine

基  金:吴阶平医学基金会临床科研专项资助基金(编号:320.6799.1096)

摘  要:目的探讨树突状细胞与细胞因子诱导的杀伤细胞(DC/CIK细胞)治疗的副反应。方法回顾性分析152例接受DC/CIK细胞治疗的癌症患者的临床资料。结果 152例患者中,肝功能异常13例,发生率为8.6%。肾功能异常12例,发生率为7.9%。心电图异常15例,发生率为9.9%。贫血8例,发生率为5.3%。发热16例,发生率为10.5%。无治疗相关性死亡。结论 DC/CIK细胞治疗可引起轻度副反应。但是,如果不给予高度重视,早期发现,早期处理,则可能导致严重后果。Objective To explore the side effects of dendritic cells and cell factors induced the killer cell (DC/CIK cells) treatment. Methods The clinical data of 152 cases of cancer patients receiving DC/CIK cell therapy were retrospectively analyzed. Results In the 152 patients, there were 13 cases of abnormal liver function, the rate of 8.6%. 12 cases of renal dysfunction, the rate of 7.9%. 15 cases of ECG abnormalities, the rate of 9.9%. 8 cases of anemia, the rate of 5.3% and 16 cases of fever, the rate of 10.5%. There was not treatment-related death. Conclusion DC/CIK cell therapy can cause mild side effects. However, if you do not attach great importance to early detection and early treatment, it may lead to serious consequences.

关 键 词:肿瘤 树突状细胞 细胞因子诱导的杀伤细胞 副反应 

分 类 号:R73[医药卫生—肿瘤]

 

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