地喹氯铵短杆菌素含片治疗智齿冠周炎临床疗效观察  

Clinical efficacy observation of dequalinium chloride tyrothricin tablet in the treatment of pericoronitis of wisdom tooth

作　　者：吴芸[1] 房宏志[1] 韩大江[1] 杨琳[1] 陈琦[1] 张翠翠[1] 

机构地区：[1]成都市第三人民医院口腔科,四川成都610031

出　　处：《中国当代医药》2013年第2期9-11,共3页China Modern Medicine

摘　　要：目的研究地喹氯铵短杆菌素含片治疗智齿冠周炎的疗效及安全性。方法本研究采用随机对照单盲评估法。选取下颌第三磨牙智齿冠周炎患者206例,在常规冠周冲洗基础上,试验组70例给予地喹氯铵短杆菌素含片含化,阴性对照组67例不使用其他局部或全身药物,阳性对照组69例给予甲硝唑口服,疗程5d。第3天和第5天复诊,进行疼痛程度、牙龈红肿、盲袋溢脓、张口受限指标及综合疗效评估,并记录不良反应。结果治疗第3天和第5天,3组患者疼痛程度、牙龈红肿、盲袋溢脓、张口受限分值均明显下降(P<0.05)。试验组与阳性对照组比较,治疗前后疼痛程度、牙龈红肿及盲袋溢脓情况的改善差异无统计学意义(P>0.05),但明显高于阴性对照组(P<0.05);而3组间张口受限改善程度比较差异无统计学意义(P>0.05)。试验组、阴性对照组、阳性对照组的总有效率治疗第3天分别为83.9%、66.7%、81.7%,治疗第5天分别为95.2%、87.7%、93.3%;试验组与阳性对照组比较,差异无统计学意义(P>0.05),与阴性对照组间差异具有统计学意义(P<0.05)。3组均无严重不良反应发生。结论地喹氯铵短杆菌素含片对智齿冠周炎有较好的辅助治疗效果及用药安全性。Objective To study the curative effect and safety of dequalinium chloride tyrothricin tablet in the treatment of pericoronitis of wisdom tooth. Methods Randomized controlled single blind evaluation method was adopted in the study. A total of 206 patients with pericoronitis of wisdom tooth in mandibular third molar were selected, and on the basis of pericoronal rinsing, 70 patients in the experimental group were given dequalinium chloride tyrothricin tablet, 67 cases in the negative control group were not given other local or systemic drug, 69 cases in the positive control group were given oral metronidazole. The course of treatment was 5 d. The degree of pain, gingival contagious tumefaction, pyorrhea of periocoronal pocket, limitation of mouth opening and comprehensive curative effect were evaluated, and adverse reaction was recorded on the third and fifth days after treatment. Results On the third and fifth days after treatment, the scores of degree of pain, gingival contagious tumefaction, pyorrhea of periocoronal pocket, limitation of mouth opening in patients of the three groups all decreased （P 0.05）. The improvements of degree of pain, gingival contagious tumefaction, pyorrhea of periocoronal pocket before and after treatment between the experimental group and the positive control group had no significant differences （P 0.05）, but they were significantly higher than the negative control group （P 0.05）, while the improvements of limitation of mouth opening among the three groups had no significant difference （P 0.05）. The total effective rates of the experimental group, negative control group and positive control group at the third day of treatment were 83.9%, 66.7% and 81.7%, which at the fifth day of treatment were 95.2%, 87.7% and 93.3% respectively, the difference between the experimental group and the positive control group had no significant difference （P 0.05）, but compared with the negative control group, the differences were significant （P 0.05）. There was no serious adverse

关 键 词：智齿冠周炎 地喹氯铵短杆菌素含片 疗效 安全性 

分 类 号：R782.31[医药卫生—口腔医学]