心原发性卵黄囊瘤临床病理观察  

Clinicopathological features of cardiac primary yolk sac tumor

作　　者：何霞[1] 季军[1] 令文萍[1] 陈小玲[1] 

机构地区：[1]深圳市孙逸仙心血管医院病理科,广东深圳518020

出　　处：《诊断病理学杂志》2013年第1期34-35,共2页Chinese Journal of Diagnostic Pathology

摘　　要：目的分析心原发性卵黄囊瘤临床病理特征及诊断、鉴别诊断要点。方法对1例发生于心的肿瘤进行组织形态学观察和免疫组化研究,结合文献探讨其病理组织特征。结果镜下见肿瘤细胞呈立方、柱状,核深染,大小不一,有异型。瘤细胞形成微囊、乳头状结构,可见SD小体、透明小体及出血、坏死。免疫组化显示CK、PLAP、AFP和AAT(+),PAS亦(+)。结论心原发性卵黄囊瘤非常罕见,由于其临床表现无特异性,早期诊断困难,诊断主要依赖于组织形态学及免疫组化检查。Abstract： Objective To study the clinicopathological features, diagnosis and differential diagnosis of cardiac primary yolk sac tumor （YST）. Methods A case of cardiac tumor was observed with histomorphologic analyses and immunohistochemical staining and the relative literature was reviewed. Results The tumor was composed of cuboidal and columnar cells with deep stained and pleomorphic nuclei. The predominant pattern was microcystic, papillary and Schiller- Dural bodies. Hyaline bodies, hemorrhage and necrosis were present. Immunohistochemically, tumor cells were positive for CK, PLAP, AFP and AAT. Conclusion Cardiac primary yolk sac tumor is rare. Early diagnosis is difficult due to its non-specific clinical manifestation. The diagnosis of cardiac YST depends on histomorphology and immunohistochemistrv.

关 键 词：心脏肿瘤 卵黄囊瘤 内胚窦瘤 

分 类 号：R732.1[医药卫生—肿瘤]