^18F-2-脱氧-D-葡萄糖PET／CT显像在评估中晚期胰腺癌患者预后中的价值  

The role of 18-fluorodeoxyglucose positron emission tomography/computed tomography imaging in predicting prognosis of patients with pancreatic carcinoma

作　　者：刘建井[1] 徐文贵[1] 戴东[1] 张凯[1] 朱研佳[1] 张莹[1] 

机构地区：[1]天津医科大学附属肿瘤医院分子影像与核医学诊疗科,天津市肿瘤防治重点实验室,300060

出　　处：《中华肝胆外科杂志》2013年第1期45-49,共5页Chinese Journal of Hepatobiliary Surgery

基　　金：天津市自然科学基金重点项目（08JCZDJC23700）;天津市教委课题（20080133）

摘　　要：目的 探讨治疗前18F 2-脱氧D-葡萄糖（^18F-FDG）PET/CT显像在中晚期胰腺癌患者预后评估中的临床价值.方法 回顾2005年4月至2011年10月临床可疑胰腺癌并行^18F-FDG PET/CT检查的106例患者资料,分析PET/CT显像及其他预后相关因素与患者生存指标之间的关系,研究PET/CT显像在中晚期胰腺癌患者预后评估中的价值.结果 Kaplan-Meier单因素分析显示,A组（SUVmax值≤7.6）与B组（SUVmax值＞7.6）患者的生存时间分别为（203.0±22.7）d与（141.0±18.2）d,差异有统计学意义（P＜0.01）；不同PET/CT分期患者之间的生存时间差异有统计学意义（P＜0.05）.Cox多因素分析显示,SUVmax值和PET/CT分期是患者长期生存的独立影响因素.结论 治疗前的^18F FDG PET/CT分期及肿瘤原发部位的SUVmax值在评估中晚期胰腺癌患者预后方面具有一定的临床价值,能够指导临床尽早制定个体化治疗方案,对提高疾病的治疗疗效、延长患者生存期具有较大意义.Objective To evaluate the role of 18F-FDG PET/CT imaging in predicting prognosis of patients with pancreatic carcinoma.Methods From April 2005 to October 2011,106 patients with clinically suspected pancreatic carcinoma were examined by 18F-FDG PET/CT.There were 57 males and 49 females.The age ranged from 33 to 85 years,with a median of 63 years.The patients were confirmed to have pancreatic carcinoma by histopathology （n 55） or by long-term clinical follow-up （n=51）.The role of PET/CT imaging in predicting prognosis of patients with pancreatic carcinoma was retrospectively analyzed.Results At the time of censor,85 patients had died,11 patients were alive and 10 patients were lost to follow-up.Kaplan-Meier analysis showed that the survival periods between patients in group A （SUVmax≤7.6） and group B （SUVmax〉7.6） were significantly different （203.0±22.7）d,（141.0±18.2）d,P〈0.01.The survival periods for patients in different PET/CT stagings were also significantly different,P〈0.05.Cox multi factor analyses indicated that the maxi-mum standardized uptake value （SUVmax） and PET/CT staging were independent risk factors of long-term survivals.Conclusions The PET/CT staging and SUV of the primary tumor before treatment were useful in predicting prognosis of patients with pancreatic carcinoma,suggesting that they can be used to guide individual treatment for patients with pancreatic carcinoma.

关 键 词：胰腺肿瘤 体层摄影术 X线计算机 诊断 预后 

分 类 号：R735.9[医药卫生—肿瘤]