胃癌伴神经内分泌分化的临床病理及预后分析  

Analysis of clinicopathological features and prognosis of gastric cancer with neuroendocrine cell differentiation

作　　者：于红梅 刘晓文 龙子雯[1,2] 张力文 周梦龙[1,2] 王亚农 

机构地区：[1]复旦大学附属肿瘤医院胃及软组织外科 [2]复旦大学上海医学院肿瘤学系,上海200032

出　　处：《中国癌症杂志》2013年第1期42-46,共5页China Oncology

摘　　要：背景与目的:胃是人体重要的具有神经内分泌功能的器官之一,部分胃癌在发生、发展过程中伴随着神经内分泌细胞分化(neuroendocrine cell differentiation,NED)现象,NED对胃癌患者预后的影响还存在争议。本研究旨在探讨胃癌伴NED的临床病理特点、治疗及预后。方法:回顾性分析复旦大学附属肿瘤医院胃及软组织外科2001年3月—2009年7月收治的17例胃癌伴NED患者和具有相同分期的34例不伴NED胃癌患者的临床资料,比较两组患者的临床病理特征和预后差异。结果:肿瘤的发生部位和分化程度与胃癌是否伴有NED具有明显相关性。伴NED的胃癌患者的1年和3年生存率明显低于不伴NED的胃癌患者的1年和3年生存率(71%vs79%,38%vs 47%,χ2=4.212,P=0.040)。多因素分析结果显示,患者年龄、浸润深度及远处转移是独立的预后因素。结论:免疫组织化学染色对伴NED胃癌的确诊具有重要价值,伴有NED可能是胃癌预后不良的重要因素之一。Background and purpose： Stomach plays an important role in neuroendocrine function, therefore some cases of gastric cancer couple with neuroendocrine cell differentiation （NED）. The prognostic significance of NED in gastric cancer patients is still in controversy. The aim of this study was to investigate the clinicopathological features, treatment, and prognosis of gastric cancer with NED. Methods： From Mar. 2001 to Jul. 2009, 17 gastric cancer patients with NED and 34 without NED having the same stage received gastrectomy in Fudan University Shanghai Cancer Center. Clinicopathological features and prognosis of the 2 groups were compared. Results： Tumor location and differentiation were significantly related with NED. The 1 and 3 years survival rates were significantly lower in gastric cancer patients with NED than in those without NED （71% vs 79%, 38% vs 47%, Z2=4.212, P=-0.040）. The Cox proportional hazard model was used in multivariate analysis. Conclusion： Immunohistochemistry is important to the diagnosis. With NED may be one of the important factors for the poor prognosis of gastric cancer patients.

关 键 词：胃癌 神经内分泌细胞分化 病理学 预后 

分 类 号：R735.2[医药卫生—肿瘤]