血管紧张素Ⅱ1型受体A1166C多态性与云南彝族原发性高血压的相关性  

Relationship between angiotensin Ⅱ type 1 receptor gene A1166C polymorphismand essential hypertension in Yi population in Yunnan province

作　　者：杨榆玲[1] 张彦[1] 龙莉[1] 吴玲[2] 瞿秋[2] 

机构地区：[1]昆明医科大学细胞生物学及遗传学系,昆明650031 [2]昆明医科大学第一附属医院干疗科

出　　处：《临床心血管病杂志》2013年第2期120-122,共3页Journal of Clinical Cardiology

基　　金：国家自然科学基金(No:81160164);云南省基金面上项目(No:2008CD117)

摘　　要：目的:研究血管紧张素Ⅱ1型受体(AT1R)A1166C多态性与云南彝族原发性高血压(EH)的相关性。方法:采用PCR-RFLP技术检测云南省晋宁县235例彝族EH患者(EH组)和180例彝族健康者(对照组)的AT1R基因A1166C多态性,并进行相关性分析。结果:EH组AA、AC+CC基因型频率为91.9%、8.1%,对照组为95.6%、4.4%;2组A1166等位基因的频率分别为95.7%和97.8%,均差异无统计学意义。在彝族女性中,EH患者AC+CC基因型和C等位基因频率明显高于对照组(均P<0.05)。结论:AT1R基因A1166C多态性可能是云南彝族女性EH的遗传易感因素。Objective： To investigate the relationship between angiotensin II type 1 receptor （AT1R） gene Al166C polymorphism and essential hypertension （EH） in Yi population in Yunnan province. Method： Two hundred and thirty-five EH patients （EH group） and 180 normal controls （normal group） of Yi population in Yunnan province were recruited. The AT1R Al166C polymorphism was determined by PCR-RFLP technique. Then the possible association between the gene polymorphism and EH was analyzed. Result：Frequencies of the AA and AC ＋CC genotypes were 91.9%, 8.1% in EH group, and 95.6% , 4.4% in normal group, respectively. Derived allele frequencies of the A1166 were 95.7% in EH group and 97.8% in normal group. There was no significant difference in A1166C genotypes distribution and allele frequencies between the two groups. But for female, frequencies of AC＋CC genotype and 1166C allele in EH group were higher than those in normal group （P〈0.05）. Conclusion：The AT1R Al166C polymorphism may be involved in the pathogenesis of EH in female of Yi population.

关 键 词：高血压 原发性 AT1R基因 遗传多态性 彝族 

分 类 号：R544.1[医药卫生—心血管疾病]