人肺鳞癌组织中Caveolin-1的表达及预后意义  

Expression of Caveolin-1 and its significance in the prognosis of lung squamous cell carcinoma

作　　者：马华玲 陈洪雷[2] 朱润庆[2] 郑明军 刘毓玲 范克非 杨为贵 

机构地区：[1]武钢总医院病理科,武汉市430080 [2]武汉大学医学院病理学教研室 [3]武钢总医院心胸外科

出　　处：《中国肿瘤临床》2013年第2期93-96,共4页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金(编号:30900652)资助~~

摘　　要：目的:研究Caveolin-1在人肺鳞癌中的表达,探讨Caveolin-1的表达与人肺鳞癌临床病理特征以及预后的关系。方法:运用免疫组织化学法检测人肺鳞癌组织中Caveolin-1、PCNA的表达,并结合患者的临床病理特征和生存情况进行分析。结果:Caveolin-1在人肺鳞癌中阳性率显著低于正常肺组织(P<0.001);Caveolin-1的表达与肺鳞癌的TNM分期(P=0.018)及淋巴结状态(P=0.006)有关。在人肺鳞癌组织中Caveolin-1与PCNA表达呈正相关(r=0.360,P=0.018)。生存分析显示肺鳞癌中Caveolin-1阳性组的生存时间显著低于阴性组(P=0.007),在24例淋巴结未转移组中Caveolin-1阳性组的生存时间显著低于阴性组(P=0.002)。多因素Cox分析显示Caveolin-1阳性表达、高临床分期、支气管残端有癌残留的肺鳞癌患者术后生存时间较短。结论:Caveolin-1的表达与肺鳞癌的恶性演进呈正相关;其可促进肺癌细胞的增殖。Caveolin-1可作为评估肺鳞癌患者的不良预后指标。Objective： This study aims to examine caveolin-1 expression in lung squamous cell carcinoma （LSCC）, to investigate the relationship of caveolin-1 expression with clinicopathological features, and to estimate the prognostic value of caveolin-1. Methods： Immunohistochemical staining was used to determine caveolin-1 and PCNA expression in LSCC. The correlation among caveolin-1 ex- pression, pathological features, and clinical outcomes were investigated. Results： The positive rate of caveolin-1 protein was significantly lower in LSCC than in normal lung tissues （P〈0.001）. Caveolin-1 expression was statistically correlated with the TNM stage （P=-0.018） and lymph node metastasis （P=0.006）. Caveolin-1 expression was also positively correlated with PCNA expression in LSCC （r=0.360; P=0.018）. The Kaplan - Meier survival curve showed that patients with positive caveolin-1 expression had a significantly shorter survival time compared with the patients with negative expression （P=0.007）. The caveolin-1-positive group had a significantly shorter survival time in 24 patients without lymph node metastasis compared with the negative group （P=0.002）. Cox multivariate analysis revealed that patients with caveolin-1 positive expression, high TNM stage, and positive surgical margin had a significantly unfavorable prognosis. Conclusion： Caveolin-1 expression is positively correlated with LSSC development as well as progression, and may promote tumor cell proliferation. Caveolin-1 may be used as a poor prognosis marker of LSCC.

关 键 词：肺鳞癌 CAVEOLIN-1 预后 

分 类 号：R734.2[医药卫生—肿瘤]