鼻咽癌患者放射治疗前后龋活性及唾液中钙、磷质量浓度的变化  

Changes of caries activity and calcium,phosphorus concentrations in saliva of patients with nasopharyngeal carcinoma before and after radiotherapy

作　　者：刘贺[1] 阙国鹰[1] 邹莉[1] 

机构地区：[1]中南大学湘雅医院口腔科,长沙410078

出　　处：《华西口腔医学杂志》2013年第1期53-56,共4页West China Journal of Stomatology

基　　金：教育部大学生创新性实验计划基金资助项目(YA09047)

摘　　要：目的探讨鼻咽癌患者放射治疗前后龋活性的变化,定量分析鼻咽癌患者放射治疗前后唾液中的钙、磷质量浓度的变化。方法选择鼻咽癌患者28例为试验组,健康志愿者20例为对照组。采用刃天青纸片法检测试验组放射治疗前、放射治疗(放射剂量为70 Gy)后龋活性的变化;采用火焰原子吸收光谱法和钼锑抗分光光度法测定试验组放射治疗前、放射治疗(放射剂量为70 Gy)后及对照组非刺激性唾液中钙、磷的质量浓度。结果试验组放射治疗后龋活性增加,与治疗前的差异有统计学意义(P<0.01)。试验组放射治疗前唾液中钙质量浓度为(63.19±3.27)mg.L-1,治疗后为(33.38±0.32)mg.L-1;放射治疗前磷质量浓度为(132.96±5.13)mg.L-1,治疗后为(49.18±2.66)mg.L-1。放射治疗前后唾液中钙、磷质量浓度的差异均有统计学意义(P<0.01),放射治疗后低于治疗前。结论鼻咽癌患者放射治疗后的龋活性增加,唾液中钙、磷质量浓度降低。Objective To analyze caries activity of nasopharyngeal carcinoma （NPC） patients before and after radiation therapy. The study was also designed to analyze calcium and phosphorus concentrations in saliva of NPC patients before and after radiotherapy. Methods Twenty-eight NPC patients and 20 healthy controls were included in this study. Resazurin disc method was used to detect caries activity of NPC patients before and after 70 Gy radiothe- rapy. The atomic absorption spectrometry and molybdenum-stibium antispetrophotography method were used to analyze calcium and phosphorus concentrations in saliva of NPC patients before and after 70 Gy radiotherapy and the healthy controls. Results The results of resazurin disc method showed caries activity of NPC patients was increased after radiotherapy（P〈0.01）. Calcium concentration in saliva of NPC patients before radiotherapy was （63.19±3.27） mg·L-1, phosphorus concentration was （132.96±5.13） mg·L-1. After 70 Gy radiotherapy, calcium concentration was （33.38± 0.32） mg·L-1, phosphorus concentration was （49.18±2.66） mg·L-~. The difference of calcium and phosphorus concen- trations in saliva before and after radiotherapy was significant （P〈0.01）. Conclusion Caries activities of NPC patients increase after radiotherapy. Calcium and phosphorus concentrations in saliva decrease after radiation therapy.

关 键 词：鼻咽癌 放射治疗 龋活性 唾液 钙 磷 

分 类 号：R739.63[医药卫生—肿瘤]