喉颗粒细胞瘤的临床分析  

Diagnosis and management of granular cell tumor of the larynx

作　　者：吕丹[1] 刘世喜[1] 余蓉[1] 朱远志[1] 杨慧[1] 

机构地区：[1]四川大学华西医院耳鼻咽喉头颈外科,成都610041

出　　处：《临床耳鼻咽喉头颈外科杂志》2013年第3期116-118,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：四川省科技厅科技支撑项目(No:2012FZ0014)

摘　　要：目的:讨论喉颗粒细胞瘤的组织发生、形态学特点和生物学行为。方法:对我科收治的3例喉颗粒细胞瘤组织形态学、组织化学及免疫组织化学染色检查进行回顾性分析,并复习国内外相关文献。结果:喉颗粒细胞瘤组织学形态学特点与其他软组织颗粒细胞瘤基本一致,但50%～60%的肿瘤表面鳞状上皮呈假上皮瘤样增生,S-100呈阳性表达,该肿瘤多起源于雪旺细胞。结论:喉部颗粒细胞瘤为罕见肿瘤,多为良性,恶性少见,预后好,多采用手术治疗。Objective：To investigate the histogenesis, morphological features and biologic behaviors of granu- lar cell tumor（GCT） of the larynx. Method： A retrospective study was performed in three cases of GCT in our hos- pital, the clinical data were studied with histopathologie analysis, histochemieal and immunohistochemical staining, and combining with the analysis of domestic and foreign literatures. Result： Histopathologic features of laryngeal GCT were identical to that in soft tissues, but pseudoepitheliomatous hyperplasia was present in 50%--60%cases of the tumor. This disease may originate from the neurogenic Schwann cell,S-100 could he positive in immunohis- tochemistry. Conclusion：Laryngeal GCT is a rare benign tumor and can be cured by local excision.

关 键 词：颗粒细胞瘤 喉肿瘤 免疫组织化学 诊断 鉴别 

分 类 号：R739.65[医药卫生—肿瘤]