驼乳对大白鼠肾病模型组织结构的影响  

Effects of Camel Milk on the Histological Structure of Nephronia Rat Model

作　　者：那仁满都呼[1] 苏布登格日勒 

机构地区：[1]内蒙古农业大学科技园区,内蒙古呼和浩特010018 [2]内蒙古农业大学兽医学院,内蒙古呼和浩特010018

出　　处：《畜牧与饲料科学》2013年第1期1-3,共3页Animal Husbandry and Feed Science

基　　金：内蒙古自治区高等学校科学研究项目(NJ09057)

摘　　要：采用组织切片方法对50只大白鼠进行了实验。按每个实验组平均体重最相近原则分为正常对照组、病理模型组、尿毒清干预组、驼乳低剂量组、驼乳高剂量组5个组,每组10只,进行为期7d的适应性饲养后, 从实验的第1天开始除正常对照组外, 其他组用腺嘌呤蒸馏水配制成浓度为 2%的混悬液, 大白鼠按200 mg/d 剂量,灌胃给药确定建立慢性肾功能衰竭模型。同时,每日15:00尿毒清干预组灌胃 25%尿毒清溶液,驼乳低剂量组、驼乳高剂量组灌予驼乳,每日1次,共28 d。停药后将大白鼠致死,取肾脏组织,制作组织切片,显微观察。结果表明,病理模型组肾小球无明显变化,肾小管及间质内有大量的中性粒细胞,部分肾小管破坏、萎缩,其中可见淋巴细胞浸润及结缔组织增生、部分肾小管扩张、肾小管上皮细胞明显增生;尿毒清干预组基本病变与投药组基本一致,但肾小管的破坏程度有所减少;驼乳低剂量组和驼乳高剂量组的病变基本与投药组相同。50 rats were tested by histological section method. 50 rats were divided into five groups：normal control group,the pathological model group, Niaoduqing intervention group,low-dose camel miLk group, high-dose camel milk group. After 7-day feeding adaptation, the rats in all groups except normal control group were administrated with 2% suspension that was prepared with adenine and distilled water with the dose of 200 mg/d by intragastric administration to establish chronic renal failure model from the first day of the test. And rats in Niaoduqing intervention group was administrated with 25% Niaoduqing solution by intragastrie administration and rats in low-dose camel milk group and high-dose camel milk group were administrated with camel milk at 15：00 of every day. After 28 days ,the rats were killed and kidney was taken out to make tissue sections for microscopic observation. The results show that glomeruli of kidney in pathological model group had no significant change and there were a large number of neutrophils in kidney tubules and interstitium. And some tubules were damaged and shunk,infiltration of lymphocytes and connective tissue proliferation, some tubular eetasia and obvious hyperplasia of tubular epithelium were seen. The basic pathological changes in Niaoduqing intervention group were basically consistent with that in drug administration groups, but the damage degree of kidney tubules decreased. The pathological changes in low-dose camel milk group and high-dose camel milk group were basically same with that in drug administration groups.

关 键 词：大白鼠 腺嘌呤 驼乳 肾脏 

分 类 号：TS252.1[轻工技术与工程—农产品加工及贮藏工程]