PGC-1α与线粒体O生成调控在心血管疾病中的作用  

Role of PGC-1α and mitochondrial biogenesis in cardiovascular diseases

作　　者：郭茜[1,2] 郭家彬[1] 李梨[2] 彭双清[1] 

机构地区：[1]军事医学科学院疾病预防控制所、毒理学评价研究中心,北京100071 [2]重庆医科大学生物化学和分子生物学教研室,重庆400016

出　　处：《中国药理学通报》2013年第1期1-5,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81072711,81102424);国家“重大新药创制”科技重大专项资助项目(No2009ZX09501-034);国家重点基础研究发展计划(973计划)资助项目(No 2011CB503803)

摘　　要：线粒体是一类高度活跃的细胞器,在细胞能量代谢等生命活动中具有重要的作用。线粒体生成,即线粒体的增殖以及线粒体系统合成和个体合成的过程。近年来研究提示,线粒体生成与线粒体的功能调节密切相关,而过氧化物酶体增殖物激活受体γ辅激活因子-1α(peroxisome proliferator-ac-tivated receptor gamma co-activator,PGC-1α)可能是线粒体生成的关键调控因子。特别是在心血管系统中,PGC-1α信号途径调控的线粒体生成可能是维持和修复心肌细胞和血管内皮细胞等心血管系统细胞线粒体功能的主要机制之一,在心力衰竭、心肌肥大、糖尿病心血管并发症等心血管疾病的发生与发展过程中具有重要作用。PGC-1α作为心血管疾病疾病预防和治疗的潜在靶标,将有可能为心血管疾病的防治提供新的策略。Mitochondrion, a class of highly active organelles, plays an important role in energy metabolism of cellular and oth- er vital activities. Mitoehondrial biogenesis is the process of mi- tochondrial multiplication, system synthesis and individual syn- thesis. Recent studies have shown that mitochondrial biogenesis is closely related to mitochondrial function. Peroxisome prolifer- ator-activated receptor gamma co-activator （ PGC-1 α） may be a key regulatory factor of mitochondrial biogenesis. Especially in cardiovascular system, mitochondrial biogenesis regulated by PGC-lα signaling pathway, could be one of the major meeha-nisms for maintaining and repairing mitochondrion function in cardiovascular system such as myocardial cells and vascular en- dothelial cells. PGC-lα plays an important role in the occur- rence and development of cardiovascular diseases such as heart failure, cardiac hypertrophy and diabetic cardiomyopathy. As a potential target, PGC-1 α could provide a new therapeutic strate- gy for the prevention and treatment of cardiovascular diseases.

关 键 词：线粒体生成 PGC-1Α 能量代谢 转录调控 信号通 路 心血管疾病 

分 类 号：R-05[医药卫生] R329