小牛血去蛋白提取物对去上皮瓣Epi-LASIK术后角膜上皮愈合的影响  

Effect of protein-free calf blood extract eye gel on cornea epithelial healing after off-flap Epi-LASIK

作　　者：尹禾[1] 沈政伟[1] 姜黎[1] 薛林平[1] 莫婷[1] 李丽[1] 吴金桃[1] 

机构地区：[1]广州军区武汉总医院眼科,中国湖北省武汉市430070

出　　处：《国际眼科杂志》2013年第2期271-273,共3页International Eye Science

摘　　要：目的:探讨小牛血去蛋白提取物对去上皮瓣Epi-LASIK术后角膜上皮愈合的影响,为改善术后眼刺激症状的临床用药提供帮助。方法:对78例156眼在我院实施去上皮瓣Epi-LASIK手术后的近视患者随机分为两组,A组为小牛血去蛋白提取物组,40例80眼;B组为对照组,38例76眼。两组术后常规给予妥布霉素地塞米松滴眼液、羟糖甘滴眼液4次/d,共7d,之后常规滴1g/L氟米龙滴眼液,4次/d,逐月递减1次,共用4mo。A组在此基础上,加用小牛血蛋白提取物眼用凝胶,4次/d,共7d。术后随访6mo,定期观察两组术后反应、角膜上皮愈合时间、视力及角膜上皮下雾状混浊(haze)情况。结果:术后A组角膜上皮平均愈合时间为2.89±1.06d,对照组为4.22±1.47d,小牛血组明显短于对照组,上皮愈合更快(t=6.45,P<0.05);术后第1d和第2d,A组反应程度评分为1.70±0.44和1.02±0.60,B组为2.89±0.43和1.71±0.55,小牛血组术后反应程度明显轻于对照组(P<0.05)。3d后术后反应两组差异均无统计学意义(P>0.05);两组患眼术后视力恢复和haze情况差异均无统计学意义(P>0.05)。结论:去上皮瓣Epi-LASIK术后应用小牛血去蛋白提取物眼用凝胶能够减轻术后反应,加快角膜上皮愈合,起效时间短,安全性较好。AIM： To observe the effect of protein-free calf blood extract eye gel on epithelial healing after Epi-LASlK, and to improve the clinical use of postoperative eye irritation. METHODS： Seventy-eight patients （156 eyes） performing off-flap Epi-LASIK were randomized into experimental and control groups. Forty patients （80 eyes） were in experimental group and thirty-eight patients （76 eyes） in control group. The two groups were treated with compound tobramycin eye drops, tears naturale eye drops for 7 days, four times a day, then the conventional artificial tears and l g/L fluorometholone were given. Protein-free calf blood extract eye gel for 7 days, four times a day were given in the experimental group, the follow-up time was 6 months, the postoperative pain, time of corneal epithelial recovery, visual acuity and corneal subepithelial opacity （haze） were examined at special time in two groups. Clinical outcomes were compared between groups. RESULTS： The mean time of corneal epithelial recovery was （2. 89±1.06） days in the experimental group and （4.22±1.47） days in the control group. Compared with the control group, outcome of rapider reepithelialization was found in the experimental group, there was statistical difference （t= 6.45, P〈0.05）. The average pain score of experimental group was （1.70±0.44） on the first day and（1.02±0.60） on the second day, the control group was （2.89±0.43） and （1. 71±0. 55）, the experimental group obviously had milder pain, there was statistical difference （P〈 0.05）. There was no significant difference in visual acuity and haze between the two groups （P 〉0.05）. CONCLUSION. Protein-free calf blood extract eye gel has effectiveness on reducing ocular pain and promoting cornea epithelial healing after Epi-LASIK, the application is safe and has shorter onset time.

关 键 词：去上皮瓣Epi-LASIK 小牛血去蛋白提取物 角膜 上皮愈合 

分 类 号：R779.63[医药卫生—眼科]