糖耐量异常患者TCF7L2基因多态性及其生活方式干预的研究进展  

Research progress on TCF7L2 gene polymorphism in patients with the impaired glucose tolerance and its lifestyle intervention

作　　者：马恩婷[1] 尹立群[2] 步怀恩[2] 窦昊颖[1] 

机构地区：[1]天津中医药大学护理学院,天津300193 [2]天津中医药大学中医学院

出　　处：《现代预防医学》2013年第4期687-689,693,共4页Modern Preventive Medicine

基　　金：天津市科技攻关项目(033113211)

摘　　要：转录因子7类似物2是糖耐量异常患者的易感基因之一,常见单核苷酸多态性位点为rs12255372和rs7903146,其变异型主要通过GLP-1信号途径降低胰岛素分泌。过多摄入热量可使转录因子7类似物2变异型加重β细胞功能损害,促进糖耐量异常向2型糖尿病转化,因此给予相应的生活方式干预对预防或延缓向2型糖尿病的转化可能具有一定的作用,但其具体的分子生物学机制尚未明确。Transcription factor 7-like 2 gene is one of susceptibility genes of impaired glucose tolerance （IGT）, with the com- mon single nucleotide polymorphisms loci at rs7903146 and rs12255372. TCFTL2 variation mainly decreases insulin secretion by changing the signal of glueagon-like peptide-1 （GLP-1）. If taking excessive calories, TCFTL2 variation can cause ~3-cell func- tion impaired and promote the conversion from IGT to type 2 diabetes mellitus （T2DM）. Thus the appropriate lifestyle interven- tion maybe benefit to prevent or delay the conversion from IGT to T2DM effectively, however, the molecular biology mechanism by which lifestyle intervention reduce the incidence of T2DM is yet not to be identified.

关 键 词：糖耐量异常 转录因子7类似物2 基因多态性 2型糖尿病 

分 类 号：R-055[医药卫生]