乙型肝炎病毒基因型与肝炎类型临床意义分析  

Analysis of clinical significance between the genotypes of HBV and the categories of Hepatitis

作　　者：陈宇宁 郭平[2,3] 罗佳[4] 黄杰[2,3] 李键红[2,3] 王健[2,3] 

机构地区：[1]新都区人民医院,四川新都610500 [2]成都市第三人民医院检验科 [3]重庆医科大学附属成都第二临床学院 [4]成都市传染病医院

出　　处：《现代预防医学》2013年第4期742-743,745,共3页Modern Preventive Medicine

摘　　要：目的探讨乙型肝炎病毒基因型在临床诊断中的意义。方法将185例确诊的乙型肝炎患者根据临床诊断分为无症状乙型肝炎携带者(ASC)、急性乙型肝炎(AHB)、慢性乙型肝炎(CHB)、肝硬化(LC)、肝细胞癌(HCC)5个疾病组,30例体检健康组作为对照,采用实时荧光定量PCR、PCR-反向点杂交等指标进行测定。结果乙型肝炎病毒基因B、C两组肝病患者中,HBV基因B型占57.8%,基因C型占42.2%,HBV-DNA载量与HBV基因型无明显差异。结论 185例肝病患者以HBAV基因B型为主,C型次之。OBJECTIVE To explore the significance of the genotypes of HBV in the clinical diagnosis. METHODS According to the clinical diagnosis, we put 185 patients into five groups, which are Asymptomatic hepatitis b carriers （ASC）, Acute hepatitis b （AHB）, Chronic hepatitis b （CHB）, Liver Cirrhosis （LC）, Hepatocellular carcinoma （HCC）. We also put 30 cases of medically healthy groups as controls to assay the tested index by using the Time Fluorescence Quantitative PCR, PCR- RLB and so on. RESULTS Among these groups of patients with the genotype of B and C, 57.8% of them carried the genotype B and the rest of them carried genotype C. There were no statistical differences in the HBV-DNA concentration and HBV geno- types. CONCLUSION It is the patients＇ quantity of genotype B that is more than the one of genotype C among the 185 patients we assayed.

关 键 词：乙型肝炎病毒 基因型 肝炎类别 临床意义 

分 类 号：R575.1[医药卫生—消化系统]