神经系统电压-门控Na^+通道与疼痛关系研究进展  

Progress of voltage-gated sodium channels in relationship with pain

作　　者：王军[1] 欧绍武[1] 王运杰[1] 邢德广[1] 

机构地区：[1]中国医科大学附属第一医院神经外科,辽宁沈阳110001

出　　处：《解剖科学进展》2013年第1期83-87,共5页Progress of Anatomical Sciences

基　　金：国家自然科学基金资助项目(No.31100770)

摘　　要：神经系统电压-门控Na+通道(Nav)是神经元产生兴奋性所需的最基本的离子通道,在神经元静息电位的维持、动作电位的产生及传导等过程中发挥着始动作用。研究发现,电压-门控Na+通道在神经系统疼痛的产生及传导等过程中亦发挥着主要的作用,而且目前已经证实电压-门控Na+通道Nav1.7、Nav1.8、Nav1.9及Nav1.3与疼痛有关,本文结合国内外关于神经系统电压-门控Na+通道与疼痛关系的研究进展及本小组的工作,对神经系统电压-门控Na+通道的结构、种类及与疼痛的关系作一综述。Voltage-gated sodium channels are the basic ion channels for neural excitability, and crucial to the resting potential and the generation and propagation of action potential in neurons. Previous studies indicated that voltage- gated sodium channels played a central role in the generation and propagation of pain in nervous system. Recent studies proved that voltage-gated sodium channels Navl.7, Navl.8, Navl.9 and Navl.3 had close relationship with pain in nervous system. The present study will review the structure, types of the voltage-gated sodium channels in nervous system, as well as its relationship with pain.

关 键 词：离子通道 神经系统 NA^+ 门控 电压 疼痛 神经元产生 NAV1 8 

分 类 号：R741.041[医药卫生—神经病学与精神病学]