经典Wnt信号通路与神经退行性疾病关系的研究进展  

The progress of relationship between canonical Wnt signaling pathway and neurodegenerative diseases

作　　者：张彩霞[1] 管英俊[1] 陈燕春[1] 于丽[1] 李晓琎[1] 

机构地区：[1]潍坊医学院组织学与胚胎学教研室,山东潍坊261053

出　　处：《解剖科学进展》2013年第1期96-99,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金(81271413);山东省科技发展计划(2012GSF11827);山东省自然科学基金(ZR2012HQ021);山东省教育厅基金(J11LF16)项目资助

摘　　要：Wnt信号通路调节多种基因的转录,参与调控生物体的生长、发育以及细胞的增殖、分化和凋亡等重要的生理病理过程。在神经退行性疾病中,经典Wnt信号通路发生改变影响神经元的增殖、分化或对神经元产生毒性作用,导致神经元功能损伤。因此,研究经典Wnt信号通路与神经退行性疾病的发病机制及其治疗的关系有重要意义。Wnt signaling pathway regulates transcription of a variety of genes, participates in regulation and control of the growth and development of the organism, and the cell proliferation, differentiation and apoptosis, and other important physiological pathological processes. The change of Wnt signaling pathway in neurodegenerative diseases can affect the proliferation and differentiation of neurons or produce toxic effects on neurons, resulting in a series of impairments related to the function. So the research to the relationship of the canonical Wnt signaling pathway with the neurodegenerative disease pathogenesis and treatment has an important significance.

关 键 词：WNT信号通路 神经退行性疾病 神经元产生 病理过程 毒性作用 功能损伤 发病机制 生物体 

分 类 号：R749.16[医药卫生—神经病学与精神病学]