Blockage of glucocorticoid receptors during memory acquisition, retrieval and reconsolidation prevents the expression of morphine-induced conditioned place preferences in mice  

作　　者：Yao-Dong FAN Hai-Chen NIU Tanzeel Huma Ling LI Gui-Mei WANG Li-Qi XU He REN Yuan-Ye MA Hua-Lin YU 

机构地区：[1]Department of Neurosurgery,The Third Affiliated Hospital of Kunming Medical University (Yunnan Province Tumor Hospital) [2]Minimally Invasive Neurosurgery Department,The First Affiliated Hospital of Kunming Medical University [3]Kunming Institute of Zoology,Chinese Academy of Sciences [4]Laboratory of Reproductive Neuroendocrinology,Department of Animal Sciences,Faculty of Biological Sciences,Quaid-i-Azam University [5]Kunming General Hospital of Chengdu Military Region,People's Liberation Army

出　　处：《Zoological Research》2013年第1期I0031-I0039,共9页动物学研究（英文）

摘　　要：Association between the reward caused by consuming drugs and the context in which they are consumed is essential in the formation of morphine-induced conditioned place preference (CPP). Glucocorticoid receptor (GRs) activation in different regions of the brain affects reward-based reinforcement and memory processing. A wide array of studies have demonstrated that blockage of GRs in some brain areas can have an effect on reward-related memory; however, to date there have been no systematic studies about the involvement of glucocorticoids (GCs) in morphine-related reward memory. Here, we used the GR antagonist RU38486 to investigate how GRs blockage affects the sensitization and CPP behavior during different phases of reward memory included acquisition, retrieval and reconsolidation. Interestingly, our results showed RU38486 has the ability to impair the acquisition, retrieval and reconsolidation of reward-based memory in CPP and sensitization behavior. But RU38486 by itself cannot induce CPP or conditioned place aversion (CPA) behavior. Our data provide a much more complete picture of the potential effects that glucocorticoids have on the reward memory of different phases and inhibit the sensitization behavior.Association between the reward caused by consuming drugs and the context in which they are consumed is essential in the formation of morphine-induced conditioned place preference （CPP）. Glucocorticoid receptor （GRs） activation in different regions of the brain affects reward-based reinforcement and memory processing. A wide array of studies have demonstrated that blockage of GRs in some brain areas can have an effect on reward-related memory; however, to date there have been no systematic studies about the involvement of glucocorticoids （GCs） in morphine-related reward memory. Here, we used the GR antagonist RU38486 to investigate how GRs blockage affects the sensitization and CPP behavior during different phases of reward memory included acquisition, retrieval and reconsolidation. Interestingly, our results showed RU38486 has the ability to impair the acquisition, retrieval and reconsolidation of reward-based memory in CPP and sensitization behavior. But RU38486 by itself cannot induce CPP or conditioned place aversion （CPA） behavior. Our data provide a much more complete picture of the potential effects that glucocorticoids have on the reward memory of different phases and inhibit the sensitization behavior.

关 键 词：ADDICTION Conditioned place preference RU38486 Glucocorticoid receptor RETRIEVAL RECONSOLIDATION Reward memory 

分 类 号：Q577[生物学—生物化学] Q427