3．0TLAVA多期动态增强扫描对前列腺癌和前列腺癌侵犯精囊腺的诊断价值  

The value of 3. 0T liver acquisition with volume acceleration MRI inevaluation of prostate cancer and seminal vesicle invasion

作　　者：李鹏[1] 杨文君[2] 陈志强[3,4] 杜奕[1] 李燕[1] 郭玉林[3] 王燕蓉[4] 王晓东[3] 侯登华[3] 蔡磊[3] 

机构地区：[1]宁夏医科大学研究生学院,宁夏银川750004 [2]宁夏医科大学基础学院 [3]宁夏医科大学总医院放射科 [4]宁夏医科大学生育力保持省部共建教育部重点实验室

出　　处：《实用放射学杂志》2013年第1期68-71,共4页Journal of Practical Radiology

基　　金：宁夏自然科学基金资助项目（NZ09110、NZ1234）.

摘　　要：目的 探讨3．0T LAVA多期动态增强扫描对前列腺癌及前列腺癌侵犯精囊腺的诊断价值。方法 对75例临床疑诊前列腺癌患者行3.0T LAVA多期动态增强扫描，分析信号强度-时间（signal intensity-time,SI-T）曲线类型，并计算达峰时间（Tmax）、最大强化程度（SImax％）和最快强化率（Rmax），比较穿刺证实阳性组与阴性组各参数之间的差异。结果 阳性组SI-T曲线以速升缓降型和速升平台型为主，阴性组以持续缓升型为主，平台型曲线良恶性病变有重叠。阳性组Tmax、SImax％、Rmax分别为（16．99±3．20）s、（1．55±0．33）％、（9．27±2．43）％，阴性组分别为（38．50±8．47）S、（1．15±0．28）％、（2．94±1．10）％，差异均有统计学意义（t=-20．16、8．11、16．60．P〈0．01）。中高分化腺癌（Gleason score2-6）与中低分化腺癌（Gleason score7-10）的Tmax、SImax％、Rmax差异均有统计学意义（t=4．98、－2．82、－5．35，P〈0．01）。受前列腺癌侵犯的精囊腺动态增强表现为早期明显强化，SI-T曲线以速升缓降型和速升平台型最多见，侵犯组与非侵犯组的Tmax、SImax％、Rmax差异均有统计学意义（t=-08．94、4．87、17．51．P〈0．01）。结论3．0T LAVA多期动态增强扫描有助于前列腺癌和前列腺癌侵犯精囊腺的诊断。Objective To investigate the value of the liver acquisition with volume acceleration（I.AVA） MRI in evaluation of prostate cancer（PCa） and seminal vesicle invasion（SVI） by PCa. Methods Seventy-five patients with suspected PCa were underwent LAVA dynamic contrast-enhanced MR imaging（DCE-MRI） with 3.0T MR system. The styles of the signal intensity-time curves （SI-T） were analyzed. The time to minimum（Tmax）, the whole enhancment degree （Slmax%） and the maximum slope （Rmax） were calcuated. The styles of SI-T curve in positive and negative group,the means of positive and negative group were analyzed re spectively. Results The most common styles of SLT curve in positive group was rapidly ascending followed with descending curve and rapidly ascending followed with plateau curve. While in negative group most SI-T curves were persistently and slowly ascending. There was an overlap between the malignant and benign lesions in plateau curve. The mean value of Tmax, SImax%, Rmax in posi- tive and negative group were （16.99±3.20）s, （1.55±0.33） %, （9.27±2.43） % and （38.50±8. ,i7）s, （1.15±0.28） %, （2.9.1±1. 10） % , respectively. They were statistically significant（t=- 20. 16, 8. 11, 16. 60, P（0. 01 ）. The mean value of Tmax, SI- max%, Rmax in the well-differentiated canneer group （Gleason score 2-6） and the poor-differentiated canncer group（Gleason score 7 10） were also statistically significant（t=4.98,-2.82,-5.35, P〈0.01）. SVI in LAVA DCE-MRI showed early enhanced, the common styles of SI-T curves were rapidly ascending followed with descending curve. The mean value of Tmax, SImax%, Rmax inSVI group and none SVI group were statistically significant（t= -8.94, 4.87, 17.51, P〈0.01）.Conelusion 3.0TDCE-MRI is helpful in diagnosis of PCa and SVI.

关 键 词：前列腺 前列腺肿瘤 磁共振成像 动态增强 

分 类 号：R737.25[医药卫生—肿瘤] R445.2[医药卫生—临床医学]