Epigenetic changes in colorectal cancer  

作　　者：Yan Jia Mingzhou Guo 

机构地区：[1]Department of Gastroenterology & Hepatology,Chinese PLA General Hospital [2]Medical College of Nankai University

出　　处：《Chinese Journal of Cancer》2013年第1期21-30,共10页

基　　金：supported by grants from the National Basic Research Program(973Program No.2012CB934002,2010CB912802);National Key Scientific instrument Special Programme of China(Grant No.2011YQ03013405);National Science Foundation of China(Grant No.81121004,81071953)

摘　　要：Epigenetic changes frequently occur in human colorectal cancer.Genomic global hypomethylation,gene promoter region hypermethylation,histone modifications,and alteration of miRNA patterns are major epigenetic changes in colorectal cancer.Loss of imprinting(LOI) is associated with colorectal neoplasia.Folate deficiency may cause colorectal carcinogenesis by inducing gene-specific hypermethylation and genomic global hypomethylation.HDAC inhibitors and demethylating agents have been approved by the FDA for myelodysplastic syndrome and leukemia treatment.Non-coding RNA is regarded as another kind of epigenetic marker in colorectal cancer.This review is mainly focused on DNA methylation,histone modification,and microRNA changes in colorectal cancer.Epigenetic changes frequently occur in human colorectal cancer. Genomic global hypomethylation, gene promoter region hypermethylation, histone modifications, and alteration of miRNA patterns are major epigenetic changes in colorectal cancer. Loss of imprinting （LOI） is associated with colorectal neoplasia. Folate deficiency may cause colorectal carcinogenesis by inducing gene-specific hypermethylation and genomic global hypomethylation. HDAC inhibitors and demethylating agents have been approved by the FDA for myelodysplastic syndrome and leukemia treatment. Non-coding RNA is regarded as another kind of epigenetic marker in colorectal cancer. This review is mainly focused on DNA methylation, histone modification, and microRNA changes in colorectal cancer.

关 键 词：遗传变化 大肠癌 表观 MICRORNA 甲基化剂 组蛋白修饰 基因启动子区 非编码RNA 

分 类 号：R735.3[医药卫生—肿瘤]