高-低氧放疗对乳腺癌术后患者心肌保护的临床研究  

The Myocardial Protection Effects of Carbogen Plus Low Concentration Oxygen Radiotherapy in Patients Underwent Eradicative Operation of Breast Cancer

作　　者：任杰 袁志 潘荣强 孙永红 文世民 

机构地区：[1]南充市中心医院肿瘤中心,南充637000

出　　处：《中国医药导刊》2012年第12期2069-2070,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨高-低氧放疗对乳腺癌术后患者的心肌保护作用。方法:乳腺癌改良根治手术后患者60例,分为高-低氧放疗组和常规放疗组,每组30例,比较两组患者放疗前和不同放疗剂量下血清肌钙蛋白T(cTnT)的浓度和阳性率变化。结果:放疗剂量达到30Gy时两组患者血清cTnT浓度均显著增高(P<0.05);放疗剂量达到50Gy时高-低氧放疗组血清cTnT浓度和阳性率显著低于常规放疗组(P<0.05)。结论:cTnT动态变化是评价放射性心肌损伤的较好指标,高-低氧放疗对乳腺癌术后患者心肌有较好的保护作用。Objective：To investigate the effects of myocardial protection effects in patients with breast cancer undergoing carbogen plus low concentration oxygen radiotherapy（CPLCOR）.Methods：Sixty patients underwent eradicative operation of breast cancer were assigned to two groups at random.One group took up CPLCOR and the other took up traditional radiotherapy.Serum cardiac troponin T（cTnT） levels were compared before and after irradiation.Results：The concentration of cTnT were significantly increased in all patients when irradiation dose was 30Gy（P0.05）.The degree of cTnT in CPLCOR group was lower than the control group when irradiation dose was 50Gy（P0.05）.Conclusion：Serum cTnT level is a useful marker for the detection of radiogenic cardionearsis,CPLCOR may be protective to the myocardium in patients underwent eradicative operation of breast cancer.

关 键 词：肌钙蛋白 乳腺癌 高-低氧 放射治疗 

分 类 号：R737.9[医药卫生—肿瘤]