甘露聚糖肽注射液降低胃肠道肿瘤术后感染发生的临床研究  

Clinical Research of Mannatide Injection in Reducing Operative Incision of Gastroenteric Tumor

作　　者：林秀峰[1] 何力[1] 

机构地区：[1]四川省医学科学院四川省人民医院外二科,成都610000

出　　处：《中国医药导刊》2012年第12期2123-2124,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨甘露聚糖肽注射液在胃肠术后抗感染中临床疗效及作用机制。方法:选择180例胃肠道肿瘤患者随机分为治疗组组98例和对照组82例,均行外科肿瘤根治术,治疗组术前3天至术后1周应用甘露聚糖肽注射液(10-20)mg/d,对照组不予应用,术后均选用抗生素滴注,观察两组的感染情况、内毒素、细胞因子(IL-2,IL-6,IL-10,TNF-a)水平的变化以及T淋巴细胞亚群(CD3+,CD4+,CD8+)和NK细胞百分率的变化。结果:治疗组与对照组胃部肿瘤患者切口感染发生率分别为6.34%、22.64%,结直肠肿瘤患者发生率分别为5.71%、28.2%,两组比较具有统计学差异(P<0.05);治疗组胃部、结直肠肿瘤患者术后T淋巴细胞、NK细胞、IL-2、IL-10水平较术前显著提高(P<0.05),对照组则无明显改变。两组患者内毒素、IL-6、TNF-α水平与术前相比均显著降低(P<0.05)。结论:甘露聚糖肽注射可通过激活机体免疫功能,降低胃肠肿瘤的术后切口感染发生率。Objective：To discuss the clinical effect and mechanism of Mannatide Injection in operative incision of gastroenteric tumor.Methods：180 patients with gastroenteric tumor were divided into treatment group（n=76）and control group（n=72） randomly,The patients in treatment group were administrated with Mannatide Injection（10~20）mg/d from 3d before operative to Post operation,and the patients in control group were not given Mannatide Injection.Operative incision,cell factor,T cells were observed before operative and Post operation.Results：Operative incision of stomach neoplasms of treatment group and control group were 6.34%、22.64%;and that of colorectal tumors were 6.34%、22.64% respectively.There were significant differences between two groups.T cells,NK cells,IL-2,IL-10 of post operation in treatment groups were superior to preoperation and the control group,and there were significant differences between two groups（P0.05）.Endotoxin,IL-6,TNF-α of post operation in two groups were decreased comparing with preoperation.Conclusion：Mannatide injection can improve the immune function of patients,enhance the body apos;s resistance to infection,reduce the infection incidence.

关 键 词：甘露聚糖肽注射液 胃肠道肿瘤 切口感染 

分 类 号：R735.2[医药卫生—肿瘤] R735.3[医药卫生—临床医学]