根除幽门螺杆菌对糖尿病胃轻瘫的疗效研究  

Clinical Effects of Eradication of Helicobacter Pylori on Diabetic Gastroparesis

作　　者：代小松[1] 陈和平[1] 张莉[1] 

机构地区：[1]四川省医学科学院四川省人民医院干部科,成都610072

出　　处：《中国医药导刊》2012年第12期2144-2145,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨根除幽门螺杆菌(HP)对糖尿病胃轻瘫(DGP)的疗效。方法:选择有HP感染的DGP患者98例,随机均分为对照组和治疗组。对照组给予多潘立酮10 mg tid,治疗10d;治疗组选择多潘立酮10mg tid,埃索美拉唑40mg bid,阿莫西林1.0 bid加呋喃唑酮0.1 bid,治疗10d,观察记录治疗前后症状、体征变化,并做X线胃排空试验。观察药物不良反应情况。结果:HP阳性DGP患者根除HP后症状缓解,总有效率91.7%,单用多潘立酮治疗组,治疗后症状缓解有效率71.4%。两组比较差异有显著性(P<0.05)。两组药物不良反应发生率差异无显著性(P>0.05)。结论:对幽门螺杆菌阳性的DGP患者根除HP可明显提高疗效。Objective：To explore the therapeutic efficacy of eradication of helicobacter pylori（HP） on diabetic gastroparesis（DGP）.Methods：98 patients with HP infection accompanied with diabetic gastroparesis were randomly divided into control group and treatment group.The patients in control group were given domperidone 10 mg tid for 10 days,while in treatment group received domperidone 10 mg tid,Esomeprazole 40 mg bid,Amoxicillin 1.0 bid and Furaxone 0.1 bid for 10 days.The variety of clinical symptoms,signs were observed before and after treatment.When the treatment finished,all patients accepted X-ray gastric emptying test.The side-effects of drugs were erahuated.Results：The improvement rate of clinical symptoms in treatment group after H.pylori eradication was 91.7 %,whereas71.4 % in control group（P0.05）.The incidences of adverse reaction were no significant difference（P0.05）.Conclusion：Hpylori eradication can increase the therapeutic effect on H.pylori positive patients with DGP.

关 键 词：糖尿病胃轻瘫 幽门螺杆菌 

分 类 号：R573[医药卫生—消化系统] R587.2[医药卫生—内科学]