血清CA125结合超声造影检查对子宫肌瘤与子宫腺肌症的鉴别诊断价值  

Clinical Value of Serum CA125 Combined with Contrast Enhanced Ultrasound in Differential Diagnosis for Hysteromyoma and Adenomyosis

作　　者：徐栋[1] 徐加英[1] 王晓莹[1] 张亦青 汪琴娟 茹融融 邱俐 姚春[1] 沈建波[1] 

机构地区：[1]浙江萧山医院,浙江杭州311202

出　　处：《肿瘤学杂志》2012年第12期956-959,共4页Journal of Chinese Oncology

基　　金：杭州萧山科技计划项目(2011321)

摘　　要：[目的]探讨血清CA125结合超声造影检查对子宫肌瘤与子宫腺肌症的鉴别诊断价值。[方法]对73例临床诊断为子宫局灶性病变的患者进行血清CA125检测、常规腔内超声及超声造影检查,并与术后组织病理结果比较。[结果]73例患者中27例(37.0%)为子宫腺肌症,46例(63.0%)为子宫肌瘤;CA125阳性24例(32.9%)。血清CA125阳性患者中,79.2%(19/24)经术后病理确诊为子宫腺肌症;血清CA125阴性患者中,83.7%(41/49)经术后病理确诊为子宫肌瘤,两者差异有统计学意义(P<0.01)。27例子宫腺肌症超声造影表现为绝大多数病灶内部呈不均匀增强,占74.1%(20/27);46例子宫肌瘤超声造影表现为绝大多数病灶区环状不均匀强化,占87.0%(40/46),两者差异有统计学意义(P<0.01)。[结论]血清CA125结合超声造影检查,可为子宫肌瘤与子宫腺肌症的鉴别诊断提供更准确的信息,具有重要的临床应用价值。[Purpose] To explore the clinical value of serum CA125 combined with contrast en- hanced ultrasound in differential diagnosis for hysteromyoma and adenomyosis. [Methods] Serum CA125 detection,endocavity ultrasound examination and contrast enhanced ultrasound were per- formed in 73 patients with focal uterine lesions.All cases were confirmed by postoperative histopathologic findings. [Results] Of 73 patients,27 cases （37.0%） were adenomyosis; 46 cases （63.0%） were hysteromyoma. Serum CA125 was positive in 24 cases （32.9%）. Of 24 cases with serum CA125 positive,79.2% （19/24） were confirmed adenomyosis by postoperative pathology;Of 49 cases with serum CA125 negative, 83.7% （41/49） were confirmed hysteromyoma by postopera- tive pathology. There was significant difference between them （P〈0.01）. Of 27 cases with adeno- myosis,74.1% （20/27） showed irregular and unhomogeneous enhancement in the whole lesion; and of 46 cases with hysteromyoma,87.0% （40/46） showed annularity irregular enhancement. There was significant difference between them （P〈0.01）. [Conclusion] Serum CA125 combined with contrast enhanced ultrasound provides more accurate information in the differential diagnosis for hysteromyoma and adenomyosis.It is of great value in clinical application.

关 键 词：子宫肌瘤 子宫腺肌症 血清 CA125 超声检查 造影剂 

分 类 号：R737.33[医药卫生—肿瘤]