IL-1α、IL-6在颅咽管瘤组织中表达的研究  

Interleukin-1a and interleukin-6 expressions in craniopharyngiomas

作　　者：张宁宁[1] 郑宜鹏[2] 陈昆[2] 黄毓婵[3] 林佳平[2] 

机构地区：[1]泰山医学院附属医院神经外科,泰安271000 [2]中山大学附属第一医院神经外科,广州510080 [3]中山大学附属第一医院麻醉科,广州510080

出　　处：《中华神经医学杂志》2013年第2期127-130,共4页Chinese Journal of Neuromedicine

基　　金：广东省自然科学基金（10151008901000238）;广东省科技计划项目（20118080701076）

摘　　要：目的探讨颅咽管瘤中白介素2α（IL-1α）、白介素6（IL-6）的表达与其病理类型、手术切除率及术后复发率的关联性及其临床意义。方法选取中山大学附属第一医院神经外科自2003年1月至2009年10月行显微外科手术切除的颅咽管瘤肿瘤标本69例．其中釉质细胞型52例，乳头鳞状细胞型17例，免疫组织化学染色检测肿瘤组织中IL-1α、IL-6的表达。分析IL-1α、IL-6表达与肿瘤病理类型、手术全切除率、术后复发率的关系。结果本组肿瘤全切除50例，次全切除13例，大部分切除6例；随访患者64例，复发9例（14．1％）；免疫组化检测显示28例标本IL-6表达阳性，3例IL-1α表达阳性：不同病理类型、术后是否复发肿瘤中IL-1α、IL-6的阳性表达率比较差异均无统计学意义（P〉0.05）；是否全切肿瘤中IL-1α阳性表达率比较差异无统计学意义（P〉0．05），而IL-6的阳性表达率比较差异有统计学意义（P〈0．05）。结论IL-6参与了颅咽管瘤与周围脑组织的炎症反应．这种炎症反应可能是颅咽管瘤手术难以全切除的一个重要影响因素。Objective To investigate the correlations of interleukin-1α （IL-1α） and IL-6 expressions in craniopharyngiomas with the pathological subtypes, removal rate and recurrence rate, and explore their clinical significance. Methods Sixty-nine pathologic specimens ofcraniopharyngiomas, collected in our hospital during the microsurgery from January 2003 to October 2009, were chosen in our study; the craniopharyngiomas were classified into two different pathological subtypes： enamel cells and nipple squamous cells. The IL-1α and IL-6 expressions were detected in craniopharyngioma tissues by immunohistochemistry. The correlations of IL-1α and IL-6 expressions in craniopharyngiomas with the pathological subtypes, removal rate and recurrence rate were analyzed statistically. Results The total tumor removal was achieved in 50 cases （72.5%）, subtotal removal in 13 cases （18.8%） and partial removal in 6 cases （8.7%）. Nine cases （14.1%） were recurrent during the follow-up. IL-6-positive expression was detected in 28 cases, and IL-1α-positive expression in 3 cases; IL-1α and IL-6 expressions in craniopharyngiomas with different pathological subtypes showed no significant difference （P〉0.05）; craniopharyngiomas with postoperative recurrence or without showed no obvious difference （P〉0.05）. The difference of IL-1α expression in patients with total removal, subtotal removal and partial removal showed no statistically significance （P〉0.05）; while that of IL-6 expression had significant difference （P〈0.05）. Conclusion IL-6 involves in the inflammatory reaction between craniopharyngioma and its surrounding brain tissues, which may be the important influencing factor of total removal of the craniopharyngioma.

关 键 词：颅咽管瘤 白介素1Α 白介素6 显微外科手术 

分 类 号：R739.41[医药卫生—肿瘤]