抑郁症与强迫症患者治疗前后血清脑源性神经营养因子、白介素-2及白介素-6水平变化及其临床意义  

The level changes of brain-derived neurotrophic factors,interleukin-2 and interleukin-6 in serum of patients with depression and obsessive-compulsive disorder before and after treatment and their clinical significance

作　　者：江鸿波 李莉欣 

机构地区：[1]云南省泸西县人民医院神经内科,云南卢西652400

出　　处：《实用临床医药杂志》2013年第1期37-40,共4页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11220224)

摘　　要：目的探讨抑郁症与强迫症患者治疗前后血清脑源性神经营养因子(BDNF)、白介素-2(IL-2)、白介素-6(IL-6)水平变化及影响因素。方法患者按症状分为抑郁症组、强迫症组、对照组,每组30例。抑郁症组和强迫症组在帕罗西汀治疗基础上,配合心理治疗。酶联免疫吸附法(ELISA)检测3组血清BDNF、IL-2、IL-6水平。治疗前后进行量表评定,抑郁症状评定采用汉密尔顿抑郁量表(HAMD),强迫症状评定采用耶鲁-布朗强迫量表(Y-BOCS)。对抑郁症、强迫症患者血清BDNF、IL-2、IL-6水平与HAMD总分值、Y-BOCS总分值、病程、年龄、性别之间进行相关分析。结果治疗后抑郁症组血清BDNF水平较治疗前明显升高,IL-2、IL-6水平较治疗前明显降低,但BDNF水平仍明显低于对照组。治疗后强迫症组血清BDNF水平较治疗前明显升高,IL-2水平较治疗前明显降低,但BDNF水平仍明显低于对照组。抑郁症组血清BDNF水平与HAMD评分呈负相关(P<0.05),血清IL-2、IL-6水平与HAMD评分呈正相关。强迫症组血清BDNF水平与Y-BOCS评分呈负相关,血清IL-6与Y-BOCS评分呈正相关。结论 BDNF、IL-2、IL-6为抑郁症、强迫症的鉴别及诊疗提供可能依据。Objective To explore the level changes of brain-derived neurotrophic factors （BDNF）, interleukin-2 （IL-2） and interleukin-6 （IL-6） in serum of patients with depression and ob- sessive-compulsive disorder before and after treatment and the influential factors. Methods There were 30 cases in depression group （depression patients）, 30 cases in obsessive-compulsive disorder group （patients with obsessive-compulsive disorder） and 30 cases in control group. On the basis of paroxetine therapy, the psychological therapy was administered in the depression group and the ob- sessive-compulsive disorder group. The levels of BDNF, IL-2 and IL-6 in serum of the three groups were detected by enzyme-linked immunosorbent assay （ELISA）. Before and after treatment, the scale assessment was conducted. Hamilton depression rating scale （HAMD） was applied to assess the symptoms of depression while yale-brown obsessive compulsive scale （Y-BOCS） to evaluate ob- sessive compulsive symptoms. The relative analysis was conducted between the levels of BDNF, IL-2 and IL6 in serum of patients with depression and obsessive - compulsive disorder and HAMD total score, Y-BOC~ total score, disease duration, age and gender. Results After treatment, serum BDNF level in the depression group significantly increased, while the levels of IL-2 and IL-6 obvi- ously decreased, but BDNF level was still lower than that in the control group. Serum BDNF lev- el in obsessive-compulsive disorder group conspicuously elevated, whereas IL-2 level markedly re- duced, but BDNF level was still lower than that in the control group. In the depression group, serum BDNF level was associated with HAMD score negatively, while the levels of IL-2 and IL-6 in serum were related to HAMD score positively. In the obsessive-compulsive disorder group, serum BDNF level is associated with Y-BOCS score negatively, while serum IL6 was related to Y -BOCS score positively. Conclusion BDNI~, lg_2 and IL-6 can provide possible evidences for the i- dentificatio

关 键 词：抑郁症 强迫症 脑源性神经营养因子 白介素-2 白介素-6 

分 类 号：R749[医药卫生—神经病学与精神病学]