舌鳞状细胞癌 PF 诱导化疗与Ki-67及 EGFR 表达的关系研究  

Research of correlations between induction chemotherapy of PF regimen with expression of Ki-67 and EGFR in tongue squamous cell carcinoma

作　　者：徐金标[1] 魏军水[1] 孙鑫[1] 

机构地区：[1]台州市第一人民医院口腔科,318020

出　　处：《浙江医学》2012年第23期1886-1888,共3页Zhejiang Medical Journal

摘　　要：目的探讨PF诱导化疗对舌鳞状细胞癌组织中增殖细胞核抗原（Ki-67）、表皮生长因子受体（EGFR）表达的影响及意义。方法采用免疫组织化学方法检测64例舌鳞状细胞癌患者诱导化疗前后肿瘤组织中Kj-67及EGFR的表达，分析其与疗效的关系。结果诱导化疗总有效率为81．2％（52／64）。诱导化疗前Ki-67阳性者经诱导化疗的疗效明显高于Ki-67阴性者（P〈0．05），化疗前EGFR阳性者经诱导化疗的疗效明显高于EGFR阴性者（P〈0．05）。诱导化疗后Ki-67阳性及EGFR阳性患者均明显减少（均P〈0．05）。结论PF诱导化疗对Ki-67、EGFR表达有明显影响，Ki-67、EGFR的表达情况对舌鳞状细胞癌诱导化疗疗效有一定预测价值。Objective To investigate the expressions of Ki-67 and EGFR in tongue squamous cel carcinoms treated by PF induction chemotherapy and their clinical significance. Methods Expressions of Ki-67 and EGFR were determined by im-munohistochemistry in 64 patients with tongue squamous cel carcinoma before and after PF induction chemotherapy. Results The overal response rate to induction chemotherapy was 81.2%. The response rate of patients with positive Ki-67 or EGFR ex-pression were higher than that with negative Ki-67 and Ki-67 expression before induction chemotherapy （P〈0.05）. The expres-sion of Ki-67 or EGFR were significantly reduced after induction chemotherapy （P〈0.05）. Conclusion The expression of Ki-67 and EGFR may be of predictive value for PF induction chemotherapy and inductive chemotherapy may affect Ki-67 and EGFR expression in patients with tongue squamous cel carcinoma.

关 键 词：舌鳞状细胞癌 诱导化疗 增殖细胞核抗原 表皮生长因子受体 免疫组织化学 

分 类 号：R739.42[医药卫生—肿瘤]