酒精干预对大(小)鼠缺血性卒中结局影响的系统评价  

In uence of Alcohol Intervention on the Outcome of Rats and Mice with Ischemic Stroke: A Systematic Review

作　　者：齐广伟[1] 郑佳[2] 赵瑞波[1] 

机构地区：[1]哈尔滨医科大学病理学教研室,哈尔滨150081 [2]哈尔滨医科大学营养与食品卫生学教研室,哈尔滨150081

出　　处：《中国循证医学杂志》2013年第2期204-209,共6页Chinese Journal of Evidence-based Medicine

摘　　要：目的系统评价酒精干预对大(小)鼠缺血性卒中结局的影响。方法计算机检索PubMed、EMbase、BIOSIS、CNKI、WanFang Data和VIP数据库中关于酒精干预用于缺血性卒中动物模型的研究,检索时间截至2012年6月。按纳入与排除标准筛选文献、提取资料和进行方法学质量评价后,采用RevMan 5.1软件进行Meta分析。结果共纳入8个研究。Meta分析结果显示:与对照组相比,酒精干预组对缺血性卒中的影响无统计学意义[MD=–6.98%,95%CI(–20.38%,6.43%),P=0.31],但低剂量急性酒精干预(≤2 g/kg)可改善缺血性卒中预后[MD=–22.83%,95%CI(–38.77%,–6.89%),P=0.005],而高浓度慢性酒精干预会加重缺血性卒中脑缺血损伤[MD=24.06%,95%CI(10.54%,37.58%),P=0.000 5]。结论低剂量酒精干预对大(小)鼠具有潜在的神经保护作用,高剂量酒精干预则可能加重其脑损伤程度。但应注意,受纳入研究发表偏倚等因素的影响,酒精干预对大(小)鼠卒中结局的影响程度可能被高估。Objective To systematically evaluate the influence of alcohol intervention on the outcome of rats and mice with ischemic stroke. Methods Databases including PubMed, EMbase, BIOSIS and CNKI were electronically searched from establishment dates of databases to June 2012 to retrieve animal experiments on the influence of alcohol intervention on the outcome of rats and mice with ischemic stroke. The relevant studies were identified according to the predefined inclusion and exclusion criteria, the data were extracted, and the quality was evaluated. Then meta-analysis was performed using RevMan 5.1 software. Results Eight studies were included. The results of meta-analysis showed that no significant difference was found between the alcohol intervention group and the control group （MD=-6.98%, 95%CI -20.38% to 6.43%, P=0.31）. However, compared with the control group, low dose of acute alcohol intervention （less than 2 g/kg） improved the prognosis of ischemic stroke with a significant difference （MD=-22.83%, 95%CI -38.77% to -6.89%, P=0.005）, and highly-concentrated of chronic alcohol intervention worsened the cerebral ischemic damage of rats and mice with a significant difference （MD=24.06%, 95%CI 10.54% to 37.58%, P=0.000 5）. Condusion Low dose of acute alcohol intervention （less than 2 g/kg） could improve the prognosis of rats and mice with ischemic stroke which has the potential neuro-protective effects. However, highly-concentrated chronic alcohol intervention could worsen the cerebral ischemic damage. Due to the limitations of the included studies such as publication bias, the influence of alcohol interven- tion on the outcome of rats and mice with ischemic stroke could be overestimated.

关 键 词：酒精 缺血性卒中 脑缺血 系统评价 META分析 动物实验 

分 类 号：R743.3[医药卫生—神经病学与精神病学]