MicroRNAs与帕金森氏病  

MicroRNAs and Parkinson′s disease

作　　者：周小爽[1] 李晔[1] 白洁[1] 

机构地区：[1]昆明理工大学医学院,昆明650500

出　　处：《生命科学》2013年第1期54-57,共4页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(81160162)

摘　　要：帕金森氏病(Parkinson′s disease,PD)是中脑黑质多巴胺能神经元进行性减少的神经退行性疾病,其发病机制尚不清楚。目前研究表明,α-共核蛋白、Parkin等基因突变,以及环境毒素、线粒体损伤与帕金森氏病有关。MicroRNAs是小片段非编码RNA,通过转录后水平调节基因表达,在神经细胞分化、增殖、凋亡中起重要作用。综述了microRNAs与PD的相关性,并分析了microRNAs在PD病理生理过程中的作用。The Parkinson＇s disease （PD） is the neuronal degenerative disorder characterized by the progressive loss of dopaminergic neuron in substantia nigra of midbrain. The exact molecular mechanism is not yet clear. The studies showed that mutations of α-synuclein gene and Parkin gene, environmental toxins, as well as mitochondrial damage were related to PD. MicroRNAs are small non-coding RNAs that regulate gene expression through post- transcriptional regulation and play roles in the neuron differentiation, proliferation and apoptosis. The microRNAs with PD correlation, and analysis of the role of microRNAs in thepathophysiological process in PD were reviewed.

关 键 词：帕金森氏病 MICRORNAS Α-共核蛋白 

分 类 号：Q522[生物学—生物化学] R742.5[医药卫生—神经病学与精神病学]