启东市非新生儿期接种乙肝疫苗儿童远期效果观察  

Long-term Protective Efficacy Against Chronic Hepatitis B Virus Infection After the Non-newborn Hepatitis B Vaccination in Qidong

作　　者：倪正平[1] 黄飞[1] 陆玲玲[1] 陈陶阳[1] 施平凡[1] 

机构地区：[1]江苏省启东市人民医院启东肝癌防治研究所,226200

出　　处：《医学理论与实践》2013年第4期421-422,426,共3页The Journal of Medical Theory and Practice

基　　金："十一五"国家攻关课题(2006BAI02A03)高危人群乙肝疫苗接种预防肝癌的随访及评价

摘　　要：目的:了解非新生儿期接种乙肝疫苗儿童的远期效果。方法:上述对象(非新生儿组)在12岁时全程接种乙肝疫苗(10μg/支),同龄的对照组(新生儿组)0岁起全程接种乙肝疫苗(10μg/支)。18岁时两组对象静脉采血,检测HBsAg、抗-HBs、抗-HBc和丙氨酸氨基转移酶(ALT)。结果:非新生儿组与新生儿组相比:前者HBsAg(8.0%)、抗-HBs(62.3%)和抗-HBc(23.1%)阳性率显著高于后者HBsAg(2.0%)、抗-HBs(37.2%)和抗-HBc(4.5%)(P<0.001)。HBsAg阳性者中抗-HBc阳性率前者为100%,后者71.4%,P=0.035;抗-HBs阳性者中的抗-HBc阳性率前者为19.7%,后者6.0%,P=0.000。ALT异常率:前者(5.4%)和后者(6.4%)无显著差异(P=0.575)。将HB-sAg分为阳性者和HBsAg阴性者且进行组内比较时,两组HBsAg阴性者的ALT异常率(前者5.1%,后者6.4%)均显著高于HBsAg阳性者(前者0.6%,后者0.0%)(P=0.000)。结论:非新生儿期接种乙肝疫苗儿童在远期(18岁)仍具有较高抗-HBs阳性率,对HBV感染具有一定保护性;但HBV的感染标志HBsAg和抗-HBc高于新生儿期接种儿童。Objective： To investigate the long-term protective efficacy against chronic hepatitis B virus infection after the non-newborn hepatitis B vaccination in Qidong. Methods： Those who received HB vaccine at their age of 12 years （non-newborn group） and at neonatal period （newborn group） were selected. Sera were collected at their ages of 18 years. HBsAg, anti-HBs , anti-H/3c and ALT were determined respectively. Results： Among the 18 years-old vaccinees who received HB vaccination at their ages of 12 years, HBsAg seropositive rate was 8. 0%, anti-HBs was 62. 3% and anti-HBc was 23. 1% respectively. Among the similar population who received neonatal HB vaccination, HBsAg seropositive rate was 2. 0%, anti-HBs was 37. 2% and anti-HBc was 4. 5% respectively. Those were significantly higher in non-newborn group than in newborn group（P〈0. 001）. In the former of HBsAg seropositive, anti-HBc seropositive rate was 100% and in the latter it was 71.4% （P=0. 035）. And of the anti-HBs seropositive,anti-Hl3c positive rate in the two groups was 19. 7% and 6. 0% respectively （P=0. 000）. But ALT abnormal rate was 5. 4% and 6. 4% respectively （P=0. 575）. The follow-up were divided into positive and negative by HBsAg. In the positive ALT abnormal rate of the two groups received HB vaccination were 5. 1%, 6. 4%. And in the negative they were 0. 6 %, 0. 0%. They were significantly higher in he former than the latter （P=0. 000）. Conclusion：The anti-HBs seropositive rate was higer in those who received HB vaccination after neonatal period at their age of 18 years. And it provided the protection against HBV infection. However their rates of HBsAg and anti-HBc were also higher than those who received neonatal HB vaccine.

关 键 词：非新生儿 新生儿 乙肝疫苗 HBsAg 抗-HBS 抗-HBC ALT 

分 类 号：R575.1[医药卫生—消化系统]