电针对缺血脑组织Survivin、VEGF表达及两者相关性影响的研究  

Research of Electro-acupuncture on the Expressions of Survivin and VEGF in Ischemic Brain Tissue and Their Associativity

作　　者：黄浏姣[1] 陈邦国[2] 洪亚群[2] 

机构地区：[1]湖北中医药大学中医临床学院 [2]湖北中医药大学针灸骨伤学院

出　　处：《山西中医》2013年第2期41-43,共3页Shanxi Journal of Traditional Chinese Medicine

基　　金：教育部高等学校博士学科点专项科研基金(项目编号:20094230110002)

摘　　要：目的:研究电针对缺血脑组织Survivin、VEGF表达及两者相关性的影响。方法:电针作用于缺血再灌注模型,免疫组化法观察缺血脑组织中心区和周围区Survivin、VEGF表达,并分析电针对其的影响,并探索两者的相关性。结果:在中心区,随着缺血时间的延长,Survivin、VEGF表达均逐渐降低;在缺血周边区,两者的表达均是先逐渐增加,到72 h达到峰值,然后逐渐降低,电针能明显促进两者的表达,与模型组比较差异均有显著意义(P<0.05)。结论:电针疗法能有效减轻脑组织缺血性损伤,且治疗介入越早效果越好,其作用机理可能与增加Survivin、VEGF表达量有关,两者在促进脑血管新生和神经保护方面有协同作用。Objective： To study the effect of electro-acupuncture on the expressions of survivin and VEGF in cerebral ischemia as well as their correlation. Methods： The model of cerebral ischemia reperfusion was treated with electro-acupuncture. Then the expressions of survivin and VEGF in the center area and the peripheral area of the ischemic brain tissue were observed with immunohistochemistry. The effect of the electro-acupuncture was ana- lyzed, and the relationship between them was investigated. Results： In the center area, with the elapse of time, the expressions of Survivin and VEGF decreased. In the ischemic peripheral zone both of the expressions were firstly increased. But until 72 h a peak reached, the expressions then gradually reduced. Electro-acupuncture could obviously promote both of the expressions, and there was significant difference between the groups （P 〈 0. 05 ）. Conclusion ： Electro-acupuncture therapy can effectively alleviate the brain ischemic injury,＂ and the soon- er the intervention goes into, the better therapeutic effect is. The mechanism of action may be associated with the increased expressions of survivin and VEGF. They have synergistic effect on promoting cerebral angiogenesis and protecting nerves.

关 键 词：脑缺血再灌注 电针 SURVIVIN VEGF 血管新生 实验研究 

分 类 号：R743[医药卫生—神经病学与精神病学]