Ki-67表达与乳腺MRI成像特点的相关性研究  

Correlation between Ki-67 and breast MR imaging features

作　　者：余娟[1,2] 彭秀斌[1] 文建荣[2] 许梅海[1] 

机构地区：[1]暨南大学附属珠海医院影像科,广东519000 [2]南华大学附属南华医院放射科,湖南421002

出　　处：《影像诊断与介入放射学》2012年第6期413-415,共3页Diagnostic Imaging & Interventional Radiology

摘　　要：目的对比研究乳腺癌磁共振成像特点与Ki-67表达的关系。方法回顾性分析140例行MR检查并经手术病理证实为乳腺癌患者,80例Ki-67表达阳性,60例阴性。结果乳腺癌Ki-67阳性组比阴性组肿瘤大(P<0.05),更倾向于显示肿块型病变(P<0.05),且更容易出现腋下淋巴结转移(P<0.05)。阳性组的ADC均值比阴性组稍高,但没有统计学意义(P=0.65)。结论乳腺癌Ki-67表达阳性者肿块更大,更易出现淋巴结转移,这可能与细胞增殖活跃相关,也提示患者预后不良。Objective To compare the MR imaging features between Ki-67 positive and negative breast cancers. Methods MRI of 140 patients with histologically confirmed Ki-67 positive （80） and Ki-67 negative （60） invasive ductal carcinomas was retrospectively analyzed. Results Ki-67 positive breast cancer was larger and more likely to show mass lesions （P〈0.05） compared to Ki-67 negative cancer that more commonly exhibited non-mass contrast enhancement. Axillary lymph node metastasis was more frequent in Ki-67 positive than Ki-67 negative cancer （P〈0.05）. The mean ADC value of Ki-67 positive cancer was not significantly higher than the Ki-67 negative cancer （P=0.65）. Conclusion Ki-67 positive breast cancer presents as larger mass with lymph node metastasis, which may be related to active cell proliferation and suggests poor prognosis.

关 键 词：磁共振成像 Ki-67增殖抗原 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤] R445.2[医药卫生—临床医学]