PTEN和P27^(kip1)蛋白在胃癌及癌前病变中的表达和意义  

Express and significance of PTEN and P27^(kip1) in gastric carcinoma and precancerous lesions

作　　者：鹿强[1] 臧爱民[1] 冯树明 

机构地区：[1]河北大学附属医院病理科,河北保定071000 [2]河北省徐水县妇幼保健院内科,河北保定072550

出　　处：《重庆医学》2013年第5期508-510,共3页Chongqing medicine

摘　　要：目的检测PTEN、P27kip1蛋白在胃癌及癌前病变中的表达,探讨其在胃癌发生、发展中的作用。方法选取胃癌手术后、肠上皮化生和不典型增生标本,以癌旁正常组织作对照,应用免疫组化SP法检测PTEN、P27kip1蛋白的表达。结果 PTEN、P27kip1在肠上皮化生组、不典型增生组、胃癌组阳性率(P<0.01)低于正常组,呈逐渐下降趋势,两者表达呈正相关(P<0.05);PTEN、P27kip1在胃癌高、中、低、未分化、黏液癌中的阳性率(P<0.05)与胃癌病理分型、生长方式相关。结论 PTEN、P27kip1蛋白表达下调与胃癌的组织类型、生物学行为呈正相关,对胃癌的早期诊断、治疗、判断预后具有指导意义。Objective To explore the expression of PTEN、P27 kipl protein in gastric carcinoma （GC） and precancerous lesion and discuss the effect in the carcinogenesis and the growth of gastric cancer. Methods 50 cases with gastric cancer were selected. 50 cases of adjacent normal tissues were as control group. SP immunohistochemical method was used to detect PTEN and P27^kip1 pro- tein expression. Results The results indicated the fact that：The expression of PTEN and P27^kip1 significantly decreased in the patients with GC,intestinal metaplasia and atypical hyperplasia （P〈0.01）, which was lower than that of the normal controls. The expression of PTEN and P27^kip1 positively correlated. The expression of PTEN and P27^kip1 in the patients with well and moderately differentiated,lower and undifferentiated,mucinous carcinoma were positive（P〈0.05）. The expression of PTEN and P27^kip1 were closely related to the pathological type and the growth pattern of gastric cancer. Conclusion The expression levels of PTEN and P27 ^kip1 protein were significantly correlated to gastric cancer type and differentiation. The detections of those proteins have positive effects on early diagnosis, treatment and prognosis.

关 键 词：胃肿瘤 免疫组化 PTEN P27^KIP1 

分 类 号：R735.2[医药卫生—肿瘤]