环氧合酶2同黑色素瘤抗原-1蛋白在胃癌患者表达的相关性和预后影响分析  

Relationship between expressions of Cyclooxygenase 2 and Melanoma-associated antigen 1 in gastric adenocarcinoma patients and its impact on prognosis

作　　者：杨晓峰[1] 梁婷[2] 

机构地区：[1]山东省临沂市人民医院急诊外科,山东临沂276001 [2]江苏省南京市江宁区东山街道社区卫生服务中心

出　　处：《疾病监测》2013年第1期50-52,共3页Disease Surveillance

摘　　要：目的检测环氧合酶-2(Cyclooxygenase-2,COX-2)和黑色素瘤抗原-1(Melanoma-associated antigen 1,MAGE-1)蛋白在胃腺癌切除组织中的表达情况及相关性分析,以及对胃腺癌患者5年生存率的预后影响。方法用免疫组织化学方法对67例胃腺癌切除组织中COX-2和MAGE-1蛋白表达进行统计,利用SPSS 19.0软件进行预后和相关性的χ2分析。结果 COX-2表达阳性率为55.2%,MAGE-1表达阳性率为46.3%,分析结果显示COX-2蛋白高表达(阳性)是降低胃癌患者5年生存率的影响因素,MAGE-1高表达(阳性)不是降低胃癌患者5年生存率的影响因素,COX-2表达同MAGE-1表达没有相关性(P=0.156)。结论 COX-2蛋白和MAGE-1蛋白在胃腺癌组织中均有较高表达,但COX-2高表达明显影响胃腺癌患者的5年生存率,尚不能得出MAGE-1蛋白高表达影响胃腺癌患者的5年生存率的结论。Objective To detect the expressions of Cyclooxygenase 2 （COX-2） and Melanoma-associated antigen 1 （MAGE-1） in resected tumor tissues of gastric adenocarcinoma patients and analyze their relationship and the impact on the 5 year survival of the patients. Methods Immunohistochemistry was used to analyze the COX-2 and MAGE-1 expressions in 67 tumor samples resected from gastric adenocarcinoma patients. Statistical analysis was conducted by chi- square test. Results COX-2 was over-expressed in 55.2% of the patients, MAGE-1 was over-expressed in 46.3% of the patients, Over expression of COX-2 was a factor to reduce the 5-year survival rate while the over expression of MAGE-1 was not an influence factor. There was no correlation between COX-2 expression and MAGE-lexpression （P = 0. 156）. Conclusion Both COX-2 and MAGE-lwere over-expressed in gastric adenocarcinoma tissues, COX-2 over expression was significantly related with low 5-year survival rate.

关 键 词：环氧合酶2 黑色素瘤抗原-1 胃癌 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤]