地龙β-环糊精包合除味工艺研究  

Study on smelly odor removal of arthworm and β-cyclodextrin inclusion

作　　者：王昶[1] 魏文峰[1] 张树明[1] 王伟明[1] 

机构地区：[1]黑龙江省中医研究院,黑龙江哈尔滨150036

出　　处：《中草药》2013年第3期282-285,共4页Chinese Traditional and Herbal Drugs

基　　金：国家重大新药创制项目(2010ZX09101-104);哈尔滨市科技局青年科技创新人才项目(2011RFQYS090)

摘　　要：目的制备地龙β-环糊精包合物,改善其溶解性及去除不良气味。方法以次黄嘌呤为指标,考察β-环糊精加入比例、温度及时间对包合工艺的影响,并进行包合物口感满意度及溶解性检测。结果地龙(生药)-β-环糊精的比例为15∶1,70℃下超声处理60 min,次黄嘌呤平均包合率为80.31%,口感满意度为90%以上,溶解度有较大改善。结论地龙β-环糊精包合工艺可行,并可有效解决地龙不良气味问题。Objective Preparing the inclusion complex of earthworm /β-cyclodextrin to improve solubility and remove smelly odor. Methods The effects of different proportions of arthworm and β-cyeiodextrin, inclusion temperature, and time on inclusion technology were observed using hypoxanthine as indicator. And the taste satisfaction and solubility of inclusion complex were tested. Results The optimal process was as follows： the earthworm （raw material）-β-cyclodextrin is 15 ： 1, ultrasonic treatment is 60 min under 70 ℃, the inclusion rate of hypoxanthine was 80.31%, the taste satisfaction rate was 90%, and the solubility was greatly improved. Conclusion The inclusion process is feasible and the smelly odor problem of earthworm is solved effectively.

关 键 词：地龙 Β-环糊精 次黄嘌呤 口感满意度 包合工艺 不良气味 溶解性 

分 类 号：R283.6[医药卫生—中药学]