老年人非甾体类抗炎药致消化道出血的临床特征分析  

Analysis of the clincal chracteristics of non-steroidal anti-inflammatory drugs caused gastrointestinal bleeding in the elderly patients

作　　者：李熳[1] 张志广[1] 陆伟[2] 夏秀丽[1] 季英兰[1] 

机构地区：[1]天津医科大学第二医院消化内科,300211 [2]天津市传染病医院

出　　处：《中国综合临床》2013年第2期132-134,共3页Clinical Medicine of China

基　　金：天津市卫生局科技基金资助项目（07KG8）

摘　　要：目的探讨老年人应用非甾体类抗炎药（NSAIDs）致消化道出血的临床特征。方法回顾性分析天津医科大学第二医院消化内科收治的NSAIDs相关性消化道出血患者308例，按年龄分为老年组（／〉65岁）208例和中青年组（〈65岁）100例，分析两组临床特征的差异。结果老年组应用NSAIDs以阿司匹林为主，占55．8％（116／208），显著高于中青年患者37．0％（37／100）（X^2=9．517，P〈0．05）；其血液常规及凝血常规指标与中青年组相比较差异无统计学意义（P均〉0．05）；老年组服用NASIDs药物后近期出血率[21．2％（44／208）]低于中青年组[63．0％（63／100）]，差异有统计学意义（X^2=52．161，P〈0．05）。老年组及中青年组消化道出血患者的溃疡病史及Hp感染史差异无统计学意义（P均〉0．05）。结论老年人NSAIDs相关消化道出血的临床特征与青年患者不同，需予以个体化治疗。Objective To investigate the clinical features of non-steroidal anti-inflammatory drugs （NSAIDs） caused gastrointestinal bleeding in the elderly. Methods We performed a retrospective analysis of NSAIDs caused gastrointestinal bleeding with 308 cases admitted to Department of Gastroenterology, The Second Hospital of Tianjin Medical University. Patients were divided into elderly group（ ≥65 years ,n =208 ） and young group（ 〈 60 years, n = 100） to make a comparative analysis of two group differences in clinical characteristics. Results The NSAIDs in the elderly taking were mainly Aspirin （ 55.8% （ 116/208 ） ）, which was significantly more frequent than that of young group （37.0% （37/100） , X^2 = 9.517, P 〈 0. 05 ）. There was no significant difference on the blood routine and coagulation between the two groups （ P 〉 0. 05 ）. The recent bleeding rate of the elderly group （21.2% （44/208）） was lower than the young group（63.0% （63/100）） （X^2 = 52. 161 ,P 〈0.05）. The two groups had no significant difference on the history of ulcer and Hp infection （ P 〉 0. 05 ）. Conclusion The clinical characteristics of NSAIDs caused gastrointestinal bleeding on the elderly were different with young or middle-aged. This infers that elderly patients need individualized treatment.

关 键 词：老年人 非甾体类抗炎药 消化道出血 阿司匹林 

分 类 号：R57[医药卫生—消化系统]