结肠癌患者血清胃泌素改变的临床研究  

Clinical study on the changes of serum gastrin level in patients with colon cancer

作　　者：顾群浩[1] 张晓东[1] 蔡照弟[1] 朱晓明[1] 沙盈盈[1] 陈徽[1] 罗振林[1] 冯寿全[1] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院胃肠外科,200437

出　　处：《中国综合临床》2013年第2期173-175,共3页Clinical Medicine of China

摘　　要：目的探讨结肠癌患者血清胃泌素浓度的改变及其与结肠癌发生、发展的关系。方法收集2010年1月至2012年1月我院外科因结肠癌手术35例患者的临床资料，结肠息肉患者28例及正常对照30名，采用放射免疫法检测结肠息肉患者、健康对照及结肠癌患者术前、术后第1、3、7天血清胃泌素浓度并进行综合分析。结果结肠癌患者血清胃泌素浓度较结肠息肉及正常对照者显著增加[分-别为（92．45±12．98）、（49．66±10．34）、（30．12±6．39）ng／L，F=9．455，P〈0．001]，梗阻型结肠癌患者显著高于非梗阻型[（129．84±15．32）、（75．34±11．45）ng／L，t：12．181，P〈0．001]；结肠肿瘤切除患者术后第1、3、7天血清胃泌素浓度较术前显著降低[（43．02±8．34）、（40．74±6．78）、（38．12±7．09）ng／L与（89．45±12．98）ng／L；P〈0．05]，但是结肠癌带瘤患者血清胃泌素浓度较术前无明显改变[（97．34±8．30）、（95．82±7．20）、（94．44±7．74）ng／L与（100．23±10．82）ng／L；P〉0．05]，两者之间的比较差异存在统计学意义（F组内=8．341，P组内=0．012，F组问=7．871，P组间=0．024）。结论结肠癌患者血清胃泌素浓度显著高于结肠息肉患者及正常对照者，肿瘤切除术后血清胃泌素显著降低，因此提示胃泌素可能参与了结肠癌的发生发展。Objective To investigate the changes of serum gastrin level in patients with colon cancer and the relationship between serum gastfin level and colon cancer occurrence and development. Methods Data of 35 patients underwent colon cancer surgery from January 2010 to January 2012 in our hospital were collected, at the same time data of 28 patients with colonic polyps and 30 cases of normal were collected as normal control. Serum gastrin levels were tested by radioimmunoassay in patients with colon cancer before surgery, 1,3, 7 d after surgery and they were analyzed. Results The serum gastrin level of patients with colon cancer was significantly increased compared with colon polyps and healthy controls （（92. 45 ± 12. 98 ） ng/L vs （49. 66 ± 10. 34） ng/L vs （30. 12± 6. 39） ng/L;F = 9. 455, P 〈 0. 001 ） ）. Serum gastrin level in patients with obstructive colon cancer was significantly higher than that in non-obstructive cancer（ （ 129.84 ± 15.32） ng/L vs （75.34 ± 11.45） ng/L,t = 12. 181 ,P 〈0. 001 ） ;Serum gastrin levels in patients who cut off colon tumor was significantly lower than before surgery（ （43.02 ± 8.34） ng/L, （ 40. 74 ± 6. 78 ） ng/L, （ 38. 12 ± 7.09 ） ng/L vs （ 89.45 ± 12. 98） ng/L;P 〈 0. 05 ）. But no significant change of serum gastrin levels in patients with the colon tumor compared with the preoperative（ （97.34 ± 8. 30） ng/L vs （95.82 ±7.20） ng/L vs （94. 44 ±7.74） ng/L vs （100. 23 ± 10. 82） ng/L; P 〉 0. 05 ）. But there was significant difference on serum gastrin levels between patients who cut off colon tumor and patients with the colon tumor（ within groups：F = 8. 341, P = 0. 012 ;between groups ： F = 7. 871, P = 0. 024 ） . Conclusion Serum gastrin levels in patients with colon cancer were significantly higher than that of patients with colon polyps and normal controls. There was also a significant reduction of serum gastfin in tumor resection, and therefore gastrin may be involved in the development of colon

关 键 词：结肠癌 胃泌素 增殖 侵袭 

分 类 号：R735.35[医药卫生—肿瘤]