艾普拉唑、阿莫西林、左氧氟沙星三联法治疗幽门螺杆菌感染的临床观察  

Clinical efficacy of triple therapy of ilaprazole,amoxicillin and levofloxacin on Helicobacter pylori eradication

作　　者：苏连明[1] 艾江[1] 孔祥红[1] 

机构地区：[1]牡丹江医学院附属红旗医院消化内科,牡丹江157001

出　　处：《实用药物与临床》2013年第1期24-25,共2页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨艾普拉唑+阿莫西林+左氧氟沙星1周疗法根除幽门螺杆菌(HP)的疗效及安全性。方法选择91例HP阳性消化性溃疡患者,随机分为2组。治疗组采用艾普拉唑(5 mg,2次/d)+阿莫西林(1 000 mg,2次/d)+左氧氟沙星(200 mg,2次/d)联合治疗。对照组采用艾普拉唑(5 mg,2次/d)+阿莫西林(1 000 mg,2次/d)+甲硝唑(400 mg,2次/d)联合治疗。两组治疗7 d后继续用艾普拉唑5 mg,1次/d,共3周。疗程结束4周后复查胃镜和HP,观察HP根除率、症状缓解率、溃疡愈合率和不良反应。结果治疗组和对照组的HP根除率分别为91.3%、73.3%(P<0.05),治疗组和对照组症状缓解率、溃疡愈合率和不良反应发生率分别为8.7%vs.6.7%、89.1%vs.84.4%、19.7%vs.17.8%,两组比较,差异均无统计学意义(P>0.05)。结论艾普拉唑+阿莫西林+左氧氟沙星三联1周疗法是根除HP的理想方案。Objective To discuss the efficacy and safety of triple therapy of ilaprazole, amoxicillin and levo-floxacin on Helicobacter pylori （Hp） eradication. Methods 91 patients with Hp infection suffering from peptic ulcer were randomized to treatment group and control group. The treatment group were administered ilaprazole （ 5 mg, twice daily） ＋ amoxicillin （1 000 mg, twice daily） ＋ levofloxacin（ 200 mg, twice daily）for a week. The control group were administered ilaprazole（5 rag,twice daily） ＋ amoxicillin（ 1 000 mg,twice daily） ＋ metronidazole（400 mg,twice dai-ly） for a week. All patients were treated with ilaprazole （ 5 mg, once daily ） for another 3 weeks. The Hp eradication, symptoms, peptic ulcer healing and side-effects were observed after 4 weeks. Results The Hp eradication rate of treat- ment group and control group were 91.3 % and 73.3 % respectively （P 〈 0. 05 ）. The symptom ameliorate rate, peptic ulcer healing rate and side-effect rate of treatment group and control group were g. 7 % vs. 6.7% （P 〉0.05） ,89.1% vs. 84.4 % （ P 〉 0. 05 ）, 19. 7 % vs. 17.8 % （ P 〉 0. 05 ）, respectively. Conclusion The triple therapy of ilaprazole, amoxicillin and levofloxacin（ 1 week）is ideal for Hp eradication.

关 键 词：消化性溃疡 幽门螺杆菌 艾普拉唑 阿莫西林 左氧氟沙星 

分 类 号：R57[医药卫生—消化系统]