LKB11AMPK!mTOR信号通路与血液肿瘤  

LKB 1 / AMPK/mTOR signaling pathway and hematological malignancies

作　　者：陈岚[1] 任立红[1] 

机构地区：[1]哈尔滨医科大学附属第二医院儿内科,150080

出　　处：《国际遗传学杂志》2013年第1期37-41,共5页International Journal of Genetics

摘　　要：血液肿瘤已成为严重威胁儿童生命的主要疾病之一，其发病率逐年升高。随着研究的不断深入，LKBl／AMPK／mTOR信号转导通路在多种常见肿瘤如乳腺癌、前列腺癌、肝癌、肺癌及淋巴瘤等的研究中凸现出日益重要的作用，并为肿瘤的治疗提供了新的靶点，成为目前研究的热点。现就LKBl／AMPK／mTOR信号通路的组成及其与血液肿瘤的关系以及分子机制作一综述。Hematological malignancies have become a serious threaten to children＇ s health, and its incidence increases yearly. Research studies have found that LKB1/AMPK/mTOR signaling pathway plays an important role in several types of cancerous cells, including human breast cancer, prostate cancer, hepatic carcinoma, lung cancer and lymphoma. The LKB1/AMPK/mTOR axis as a new target has become a interesting topic. This review aims to discuss the relationship between LKB 1/AMPK/mTOR and hematological malignancies.

关 键 词：腺苷酸活化蛋白激酶 哺乳动物雷帕霉素靶蛋白 血液肿瘤 

分 类 号：R733[医药卫生—肿瘤]