几种环境污染物质在体检人群中的内暴露水平  

Determination of several environmental contaminants in human body

作　　者：雷雅静[1] 朱银焕 施卫星[3] 那仁满都拉[1] 陈枢青[1] 

机构地区：[1]浙江大学药学院药理毒理与生化药学研究所,浙江杭州310058 [2]杭州爱贝亚检测技术有限公司,浙江杭州310051 [3]浙江大学医学院公共卫生系,浙江杭州310058

出　　处：《浙江大学学报（医学版）》2013年第1期14-18,共5页Journal of Zhejiang University(Medical Sciences)

基　　金：浙江省重大科技专项基金(2010C13006);浙江省卫生科研基金(2011KYA044)

摘　　要：目的:测定体检人群中几种常见环境污染物质的含量,了解这些环境污染物质在正常人群中的内暴露程度。方法:采用GC、GC-MS、HPLC、ELISA等方法,对80例体检人群尿样中环境污染物的含量进行检测。结果:甲醛和甲苯的检出率分别为97.6%和41.2%;黄曲霉毒素M1(aflatoxin M1,AFM1)的检出率为91.4%;邻苯二甲酸二丁酯(dibutyl phthalate,DBP)的检出率为75.3%;有机磷的检出率在1.2%～41.2%之间;三种多氯联苯(polychlorinated biphenyl,PCBs)、氯丙嗪(chlorpromazine,CPZ)和4,5-二氯儿茶酚(4,5-dichlorocatechol,4,5-DCC)的检出率较低,检出人数均少于5例;三甲基氯化锡(trimethyltin-chloride,TMT)未检出。结论:部分环境污染物在体检人群中的内暴露程度较高,其对人体的影响和限值研究亟待加强。Objective： To detect common environmental pollutants in human body. Methods： Urine samples were collected from 80 healthy subjects. Chromatography mass spectrometry （GC-MS） , HPLC and ELISA were applied to detect several common environmental pollutants in urine samples. Results： DBP and methylbenzene were present in 75.3% and 41.2% of urine samples. The methanal and AFM1 were found in most of urine samples （approximately 91 -97% ）. By contrast, PCBs, CPZ,4,5-DCC were found in less than 5 samples, but there was no TMT detected. Conclusion： Some of the environmental pollutants including carcinogens are detected in urine samples in this study.

关 键 词：环境污染物 职业暴露 尿 分析 甲醛 甲苯 黄曲霉毒素M1 酶联免疫吸附测定 色谱法 高压液相 气相色谱-质谱法 色谱法 气相 

分 类 号：R194.3[医药卫生—卫生事业管理]