全基因组序列分析——揭示肿瘤发生发展及个体化治疗的新途径  

Whole-genome sequencing:a new approach for understanding of pathogenesis and individualized treatment of cancer

作　　者：潘映秋[1] 张伟[2] 陈枢青[2] 

机构地区：[1]温州医学院附属浙江省台州医院中心实验室,浙江临海317000 [2]浙江大学药学院药理毒理与生化药学研究所,浙江杭州310058

出　　处：《浙江大学学报（医学版）》2013年第1期103-108,共6页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金资助项目(No.81273578);台州市科技计划资助项目(No.091KY04)

摘　　要：随着全基因组测序技术的发展和测序成本的下降,以及全基因组测序技术与DNA甲基化和组蛋白乙酰化等表观遗传学分析手段的结合,对大量样本进行全面系统的分析已经成为现实,人类已具备了重新认识肿瘤发生发展的能力。从以往的不同个体之间的全基因组序列的比对,到最近大量自身不同组织的横向比对,自身基因组的纵向比对,新思路层出不穷,个体化诊治肿瘤已显露出光明的前景。With the development of sequencing technology,the cost of whole-genome sequencing was significantly declined. Meanwhile, with the application of combined whole-genome sequencing with epigenetic analysis on methylation and histone acetylation,the comprehensive and systematic analysis of numerous samples became a reality and we are able to re-understand the genesis and development of cancer. New ideas are emerging in comparative genomics research methods, from comparison of genomes among different individuals to horizontal self-comparison of different tissues and vertical self-comparison of genomes recently. Individualized diagnosis and treatment of cancer has shown a bright future.

关 键 词：基因组 碱基序列 遗传 序列同源性 核酸 序列比对 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]