T型钙通道生理病理学功能及其分子调节机制  

Physiological and pathophysiological significance of T-type calcium channels and the molecular modulation mechanisms

作　　者：黄东阳[1] 刘雅妮[1] 张海林[1] 

机构地区：[1]河北医科大学药理教研室,河北石家庄050017

出　　处：《中国药理学通报》2013年第2期166-169,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金重点项目(No 30730031);国家重点基础研究发展计划"973"子计划课题(No 2007CB512102)

摘　　要：T型钙通道是钙通道家族中重要的一员,又名低电压激活钙通道。T型钙通道不仅有重要的生理学意义,同时在病理状态下如癫痫,自闭症,高血压,心脏病,疼痛和癌症等也有很重要的作用。因此,了解T型钙通道的功能调节有重要意义。目前对T型钙通道的分子调节机制虽然有了相当的了解,但仍有许多不明之处。现对T型钙通道的生理病理学功能及其已发现的分子调节机制进行综述。T-type calcium channel,or low voltage-activate calcium channel,is an important subtype of the calcium channel family.T-type calcium channels not only play a critical role in the physiological states,but also are involved in the pathophysiological processes,such as epilepsy,autism spectrum disorder,hypertension,heart diseases,pain and cancer.Therefore it is important to understand the regulation mechanisms of T-type calcium channels.Our current understanding of the precise underlying molecular mechanisms remains relatively limited,but many new insights into the T-type channel regulation were gained in the last years.In this review,the recent progress on the understanding of the physiological and pathophysiological roles of the T-type calcium channel and the molecular modulation mechanisms are discussed.

关 键 词：电压门控性钙通道 T型钙通道 分子基础 Cav3 生理病理学功能 分子调节机制 疾病 

分 类 号：R-05[医药卫生] R329.24