老年Ⅰ期非小细胞肺癌立体定向放疗疗效观察  

Clinical research of stereotactic body radiotherapy in elderly patients with stage Ⅰ non-small cell lung cancer

作　　者：张胜[1] 曹远东[1] 孙新臣[1] 刘永彪[1] 杨焱[1] 唐心宇[1] 李彩虹[1] 李金凯[1] 裴忠玲[1] 王亭亭[1] 

机构地区：[1]南京医科大学附属第一医院放疗中心,江苏南京210029

出　　处：《东南大学学报（医学版）》2013年第1期67-70,共4页Journal of Southeast University(Medical Science Edition)

摘　　要：目的:探讨老年Ⅰ期非小细胞肺癌(NSCLC)体部立体定向放疗(SBRT)的近期疗效及安全性。方法:回顾性分析经SBRT治疗的5例老年Ⅰ期周围性NSCLC患者,给予肿瘤病灶50 Gy/5 F,95%以上剂量线覆盖PTV50的靶区范围,分别于放疗结束后1个月和3个月复查胸部CT,观察近期疗效,并评价急性放疗反应。结果:放疗结束后1个月复查评价疗效,1例完全缓解(CR),4例部分缓解(PR),放疗结束后3个月评价疗效,4例达CR,1例PR,有效率达100%,生活质量也明显改善,没有发现可评价的急性放射性肺炎表现及骨髓抑制。5例患者中皮肤反应均为1级。结论:SBRT治疗老年Ⅰ期NSCLC是一种安全、有效的治疗手段。Objective： To assess early efficacy and safety of stereotactic body radiotherapy（SBRT） in elderly patients with stage I non-small cell lung cancer. Methods：Five elderly patients with peripheral stage I non- small cell lung cancer were retrospectively analysed. All of the five patients accepted SBRT, tumor range accepted 50 Gy/5 F, the line above 95% coverage the target range of PTV50. Chest CT was assessed one month and three months after radiotherapy respectively, early efficacy was observed, and the acute radiation reaction was evaluated. Results： Five patients had CT scan, 1 month after radiotherapy, one case reached CR, other 4 cases PR, 3 months later 4 cases were CR, only one was PR, the effective rate was 100%, quality of life was also improved significantly. It found no performance evaluation of acute radiation pneumonitis and bone marrow suppression. Skin reactions of 5 patients were Ⅰ. Conclusion： For elderly patients with stage a safe, effective treatment. non-small cell lung cancer,SBRT isa safe, effective treatment.

关 键 词：非小细胞肺癌 体部立体定向放疗 近期疗效 

分 类 号：R734.2[医药卫生—肿瘤] R815[医药卫生—临床医学]