^(13)C-尿素呼气试验定量值与胃黏膜病变程度的相关性  

Correlation between ^(13)C-urea breath test value and severity of gastric mucosal lesions

作　　者：张丽颖[1] 李振华[2] 李保双[2] 蔡毅东[2] 唐旭东[2] 

机构地区：[1]中国中医科学院研究生院,北京市100700 [2]中国中医科学院西苑医院,北京市100091

出　　处：《世界华人消化杂志》2013年第2期177-181,共5页World Chinese Journal of Digestology

基　　金：中医药行业科研专项基金资助项目;No.201007006~~

摘　　要：目的:探讨13C-尿素呼气试验定量检测值与胃黏膜病变程度的关系.方法:74例患者于1wk内分别测定13C-尿素呼气试验定量检测和行胃镜检查取胃黏膜,进行组织病理学检查,黏膜按标准予以评分.将13C-尿素呼气试验定量值和胃黏膜病理病变评分做相关性分析.结果:13C-尿素呼气试验定量值与胃窦黏膜慢性炎症(r=0.9958,P=0.0001)、萎缩(r=0.2498,P=0.0318)、肠化(r=0.2784,P=0.02)病变程度呈正相关,与其活动性炎症(r=0.1979,P=0.09)病变程度不相关;13C-尿素呼气试验定量值与胃角黏膜活动性炎症(r=0.6223,P=0.0001)、慢性炎症(r=0.5480,P=0.0001)、萎缩(r=0.6014,P=0.0001)病变程度呈正相关,与其肠化(r=0.1308,P=0.27)病变程度不相关;13C-尿素呼气试验定量值与胃体黏膜活动性炎症(r=0.2039,P=0.08)、慢性炎症(r=0.0966,P=0.41)、萎缩(r=0.1369,P=0.24)、肠化(r=0.1837,P=0.12)程度均不相关;13C-尿素呼气试验定量值与全胃黏膜活动性炎症(r=0.9958,P=0.0001)、慢性炎症(r=0.9843,P=0.0001)、萎缩(r=0.9921,P=0.0001)、肠化(r=0.9934,P=0.0001)病变程度均呈正相关.结论:13C-尿素呼气试验定量值与胃黏膜病理病变程度呈正相关,临床上可以根据13C-尿素呼气试验定量值高低考虑黏膜病理病变程度,进而更好地指导临床诊断、用药及预后.AIM： To explore the correlation between 13^C-urea breath test （UBT） value and severity of gastric mucosal lesions. METHODS： Seventy-four patients who underwent the 13^C-UBT and gastroscopy within 1 week were included in the study. The severity of gastric mucosal lesions was graded pathologi cally. The correlation between 13^C-UBT value and the score of gastric mucosal lesions was ana lyzedRESULTS： 13^C- UBT value was positively correlated with the severity of chronic inflammation （r = 0.9958, P = 0.0001）, atrophy （r = 0.2498, P = 0.0318） and intestinal metaplasia （r=0.2784, P =0.02） in the gastric antrum mucosa, but not positively with that of active gastritis in the same site （r = 0.1979, P = 0.09）. 13^C-UBT value was positively correlated with the severity of active inflammation （r = 0.6223, P = 0.0001）, chronic inflammation （r = 0.5480, P = 0.0001） and atrophy （r = 0.6014, P = 0.0001） in the gastric angle mucosa, but not positively with that of intestinal meta plasia in the same site （r = 0.1308, P= 0.27）. 13^C- UBT value was not positively correlated with the severity of active inflammation （r = 0.2039, P = 0.08）, chronic inflammation （r = 0.0966, P = 0.41）, atrophy （r= 0.1369, P = 0.24）, or intestinal metaplasia （r = 0.1837, P = 0.12） in the gastric body mucosa. 13^C-UBT value was positively correlated with the severity of active inflammation （r = 0.9958, P = 0.0001）, chronic inflammation （r = 0.9843, P = 0.0001）, atrophy （r = 0.9921, P = 0.0001） and intestinal metaplasia （r =0.9934, P = 0.0001） in the whole gastric mucosa.CONCLUSION： 13^C-UBT value positively correlates with severity of gastric mucosal lesions. 13^C-UBT quantitative detection may be used clinically to assess the severity of gastric muco- sal lesions.

关 键 词：13C-尿素呼气试验 胃黏膜 病理 

分 类 号：R573[医药卫生—消化系统]