224例病理学结果为ASCUS的进一步分析  

Analysis of pathological results of 224 patients with ASCUS

作　　者：颜怀军[1] 余剑敏[2] 徐超[1] 

机构地区：[1]空军杭州疗养院,杭州310007 [2]同济大学附属第一妇婴保健院,上海200040

出　　处：《中国卫生检验杂志》2013年第1期179-181,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:分析ASCUS患者的病理学检测和HPV检测结果,为临床诊断和治疗提供依据。方法:回顾性分析224例ASCUS患者的高危型HPV检测、活检病理和LEEP病理学结果。结果:224例ASCUS患者中活检病理和LEEP病理结果为CIN1及以上病变的比例分别为73.6%和62.5%。高危型HPV阳性和阴性ASCUS患者中CIN1及以上病变者分别为79.7%和71.9%。活检病理结果为CIN1的患者中有18例LEEP病理结果为CIN2/3,其中12例为高危型HPV阳性。地域因素为ASCUS患者病理学结果为CIN1及以上病变的独立风险因素(OR=3.285,P=0.028)。结论:ASCUS患者中CIN1及以上病变患者比例较高,联合高危型HPV和活检病理对宫颈癌高发区域ASCUS患者的进一步诊断具有重要价值。Objective：To analyze the pathological results of patients with atypical squamous cells of undetermined significance（ASCUS）,and provide evidence for clinical diagnosis and treatment.Methods： A total of 224 cases of ASCUS patients were retrospectively analyzed for their results of high risk human papillomavirus（HPV） screening,biopsy,and Loop electrosurgical excisional procedure（LEEP） pathology.Results： Among the 224 ASCUS patients,the proportion of patients with CIN1 and higher neoplasia were 73.6% and 62.5% by biopsy and LEEP respectively.CIN1 or higher neoplasia was detected in 79.7% and 71.9% of patients with positive and negative HPV,respectively.Among patients with CIN1 by biopsy,18 cases were CIN 2/3 by LEEP pathology,and 12 cases were HPV positive.Area where the patients lived was an independent risk factor of CIN1 or higher neoplasia in ASCUS patients（OR=3.285,P =0.028）.Conclusion： Most of the ASCUS patients in our study had CIN1 or higher neoplasia.Combination of high risk HPV detection and biopsy may be useful for further diagnosis of ASCUS.

关 键 词：ASCUS 人乳头瘤病毒 CIN LEEP 活检病理 

分 类 号：R737.33[医药卫生—肿瘤]