MSR1基因多态性与缺血性脑卒中遗传易感性的关联研究  

Investigation on relationship between ischemic stroke and polymorphism of macrophage scavenger receptor 1(MSR1) gene

作　　者：徐正琴[1] 谢文卫[1] 徐勇[1] 徐益鸣[2] 

机构地区：[1]金坛市中医医院检验科,江苏213200 [2]南京医科大学动脉粥样研究中心,210000

出　　处：《齐齐哈尔医学院学报》2013年第1期2-5,共4页Journal of Qiqihar Medical University

摘　　要：目的探讨巨噬细胞清道夫受体1(MSR1)基因多态性与缺血性脑卒中的相关性。方法应用连接酶特异检测技术及TaqMan等位基因分型技术,在110例缺血性脑卒中患者和100例正常对照组之间对MSR1基因的rs416748、rs433235、rs12718376及rs4333601四个多态性位点进行检测。结果 MSR1基因rs416748位点基因多态在缺血性脑卒中病例组和正常对照组间的分布差异有统计学意义;应用二元对数回归统计法,在校正了性别、年龄、BMI、吸烟及高血压后,rs416748突变型等位基因A可显著增加缺血性脑卒中的患病风险。MSR1基因rs433235,rs12718376及rs4333601各位点基因多态在缺血性脑卒中病例组和正常对照组间的分布差异未达统计学差异水平(P>0.05),与缺血性脑卒中发病风险无显著相关性。结论 MSR1基因rs416748多态性位点可能与中国汉族人群缺血性脑血管病遗传易感性有关;MSR1基因多态性有可能是中国人群缺血性脑血管病高危人群筛选的标志和干预靶点。Objective To investigate the relationship between ischemic stroke and the polymorphism of macrophage scavenger receptor 1 （MSR1） gene. Methods Using the ligase detection reaction - based SNP typing technology and the TaqMan SNP typing technology, four polymorphic sites in the MSR1 gene including rs416748, rs433235, rs12718376 and rs4333601 were analyzed in a hospital- based case -control study with 110 ischemic strokes and 100 control. Results Allele frequency for rs416748 polymorphic site was statistically different between patients with ischemie stroke and unaffected contTol subjects. When adjusted f^r age, sex, BMI, smoking status and hypertension by binary logistic regression, there was significantly elevated risk for ischemic stroke among the genetic variants with high frequency of allele ＂A＂ for rs416748. Conclusions The rs416748 polymorphic site of MSR1 gene might be associated with increased risk of ishemic stroke in the Chinese population and also might be a potential marker served in clinical treatment and diagnosis.

关 键 词：缺血性脑卒中 单核苷酸多态性 病例-对照研究 MSR1 

分 类 号：R743.3[医药卫生—神经病学与精神病学]