PEDF在前列腺癌患者血清中的表达及临床意义  

Evaluation of the expression of PEDF in blood serum of prostate cancer patients and its clinical significance

作　　者：舒博[1] 陈鹏[1] 牛越[1] 张玲[2] 

机构地区：[1]新疆医科大学附属肿瘤医院泌尿科,乌鲁木齐830011 [2]新疆维吾尔自治区疾病预防控制中心

出　　处：《临床泌尿外科杂志》2013年第2期131-132,135,共3页Journal of Clinical Urology

基　　金：新疆维吾尔自治区自然科学基金(编号2010211A29);中国博士后科学基金面上资助第45批项目(编号20090451516)

摘　　要：目的:探讨色素上皮衍生因子(pigmentary epithelium derived factor,PEDF)在前列腺癌患者血清中表达并探讨其临床意义。方法:应用免疫印迹(Western blotting)法检测前列腺癌转移(PCaM)患者、前列腺癌未转移(PCa)患者及良性前列腺增生(BPH)患者血清中PEDF表达情况,并通过统计学方法比较各组PEDF的表达差异。结果:PEDF在BPH组血清样本中高于PCa组(P<0.05),PEDF在PCa组的血清样本中也高于PCaM组(P<0.05)。结论:PEDF与前列腺癌的发生和转移相关,并可能在前列腺癌的进展中起重要作用,借助测定PEDF的表达可以协助前列腺癌的诊断和预后评估。Objective：To detect the expression ot pigmentary epithehum derived tactor （PEDF） m the blood se- rum of prostate cancer and evaluation its clinical significances. Method：Western blotting method was used to detect PEDF expression in prostate cancer patients with metastasis （PCaM）, prostate cancer patients without metastasis （PCa） and benign prostatic hyperplasia patients（BPH）. Result：PEDF was more highly expressed in the blood ser- um of BPH patients than PCa patients （P〈0.05）. PEDF was also more highly expressed in the blood serum of PCa patients than PCaM patients （P〈0.05）. Conclusion： PEDF are related to the malignant transformation and metastatis of prostate cancer. To detect the expression of PEDF may make for judging prostate cancer＇s diagnosis and prognosis.

关 键 词：色素上皮衍生因子 前列腺癌 免疫印迹法 

分 类 号：R737.25[医药卫生—肿瘤]