自制二级铜性微弹簧圈栓塞血管的实验研究  

Experimental study of vascular embolization with homemade second-level Copper coil

作　　者：姜华[1] 王家平[1] 李迎春[1] 童玉云[1] 杨青[1] 闫东[1] 丁丽丽[1] 袁曙光[1] 

机构地区：[1]昆明医科大学第二附属医院放射科,650101

出　　处：《中华放射学杂志》2013年第2期183-187,共5页Chinese Journal of Radiology

摘　　要：目的探讨自制二级镀铜铂金微弹簧圈对兔血管栓塞的效果。方法选取新西兰大耳兔17只，常规麻醉后，采用自制的二级镀铜铂金微弹簧圈（实验组）经3F微导管释放，栓塞一侧锁骨下动脉或颈总动脉，然后再采用相同规格的二级铂金微弹簧圈（对照组）栓塞对侧锁骨下动脉或颈总动脉作栓塞对照分析；分别于栓塞术后10、30min，3d，1、2、4、6、12周造影观察血管闭塞情况，于栓塞术后3d，1、2、4、6、12周取被栓塞血管观察血栓形成情况和病理学改变。实验组和对照组间血管闭塞情况及血栓形成状况的比较采用确切概率法和秩和检验进行统计学分析。结果17只兔中15只完成栓塞实验。实验组栓塞兔15只，共用二级镀铜铂金微弹簧圈21枚；对照组栓塞兔15只，共用二级铂金微弹簧圈19枚。栓塞后10、30min，血管造影显示，2组间血管栓塞效果差异无统计学意义，3d，1、2、4、6、12周时，实验组血管栓塞的效果均优于对照组，差异有统计学意义（P〈0．01）。病理检查显示，实验组铜圈周围及其内部、血管远近端有大量的血栓。对照组弹簧圈周围仅见少量血栓，实验组各观察点的血栓形成情况均优于对照组（P〈0．01）。结论二级镀铜铂金微弹簧可经4F及以下导管释放栓塞迂曲血管，栓塞效果肯定，其记忆性、柔韧性、可控性、释放性及稳定性优于二级铂金微弹簧圈。Objective To evaluate the embolic effect of homemade copper coil in rabbits. Methods Seventeen New Zealand Big Ear Rabbit was included in this study. After conventional anesthesia, one common carotid artery or subclavian artery was embolized with second-level copper coated platinum micro-coils（ experimental group ） through a 3F catheter, and the other common carotid artery or subclavian artery was embolized with second-level platinum micro-coils （control group） as control. Angiography was processed to observe the extent of vascular occlusion 10 min,30miu,3 d, 1 w,2 w,4 w,6 w,and 12 w after embolization respectively. The rabbits were sacrificed to observe thrombosis and pathological change of the embolic artery 3 days,1 w,2 w,4 w,6 w and 12 w after the embolization. Vascular occlusion and thrombosis were compared between experimental group and the control group by using the exact probability method and rank sum test for statistical analysis. Results Embolization experiment was successfully implemented in 15 of 17 rabbits. Twenty-one second-level copper coated platinum micro-coils were used in the experimental group, while 19 second-level platinum micro-coils were used in the control group. Ten rain and 30 min after embolization, angiography showed that vascular embolization effect was not significantly different between the two groups. The vascular embolization effect of the experiment group was superior to control group 3 d, 1,2, 4,6 and 12 w after embolization （P 〈 0. 05 ）. Pathological examination showed that there were a lot of blood clots around the copper coil and in the proximal and distal arterial lumen. Only a small amount of blood clots was found around the platinum coil in the control group. For every time point of observation, thrombosis was more severe in the experiment group than that in the control group（ P 〈 0. 05 ）. Conclusion Second-level copper coated coil can be released with 4F catheter to embolize the vessel, showing good physical property, flexibility and medical performa

关 键 词：设备设计 兔 栓塞 铜 

分 类 号：R-332[医药卫生]