受DNA甲基化调控的microRNA在妇科肿瘤中的研究进展  

Research Progress of MicroRNA DNA Methylation in Gynecological Cancer

作　　者：巫剑红[1] 代荫梅[1] 

机构地区：[1]首都医科大学附属北京妇产医院,北京100026

出　　处：《肿瘤学杂志》2013年第1期25-28,共4页Journal of Chinese Oncology

基　　金：北京市教委科技计划面上项目(KM201010025022)

摘　　要：microRNA(miRNA)是一类长约22个核苷酸的非编码小RNA,转录后水平调节基因的表达,在个体发育,细胞的增殖、凋亡、分化中发挥重要的作用。近年来研究发现,DNA甲基化可能是妇科肿瘤中miRNA表达异常的调控机制,包括癌基因miRNA低甲基化活化和抑癌基因miRNA高甲基化失活,从而导致下游靶向基因表达异常,参与妇科肿瘤的发生发展。文章主要就miRNA的DNA甲基化在妇科肿瘤中的研究进展作一综述。MicroRNAs （miRNAs） are 22 nucleotides long non-coding RNA that regulate expression of protein-coding genes at the posttranscriptional level. These single-strand RNAs are considered to play crucial roles in many normal cellular processes,such as proliferation,differentiation, and apoptosis. Recent studies have shown that miRNA genes might be silenced in human tumors by aberrant hypermethylation or hypomethylation of miRNAs in gynecological cancer, which induce abnormality expression of downstream target gene and anticipate carcinogenisis of gynecological cancer.

关 键 词：MICRORNA DNA甲基化 妇科肿瘤 

分 类 号：R737.3[医药卫生—肿瘤]