生产性制备多克隆抗体诱发载体选择家兔的可行性研究  

Feasibility Study of Select Rabbit for Production Preparation Polyclonal Antibody Induced Carrier

作　　者：颜瑞巧[1] 周师洁[2] 江洪涛[2] 吴萍[2] 孙红斌[1] 李卫东[2] 

机构地区：[1]九江学院附属医院,江西九江332000 [2]江西省系统生物医学重点实验室(九江学院),江西九江332000

出　　处：《科技广场》2012年第12期214-216,共3页Science Mosaic

基　　金：江西省教育厅重点项目(编号:赣科技字〔2006〕303)

摘　　要：目的:探讨在生产性制备多克隆抗体使用家兔的可行性,为替代普通级实验兔提供依据。方法:采用普通级实验兔与家兔在免疫前血清背景,诱发抗体数量和质量进行对比研究。结果:实验兔和家兔血清背景检测无明显差异,三次免疫后抗体效价无明显差异,兔单位体重诱发抗体冻干物重量无差异。结论:在生产性制备兔多克隆抗体中选择家兔部分替代普通级实验兔是可行的。Objective：To investigate the feasibility of domestic rabbits, as a substitute for general experimental rabbits, as production preparation polyclonal antibody induced carriers. Methods： To observe the difference of serum background before immune, the quality and quantity of induced antibody between domestic rabbits and general experimental rabbits. Result： There is no significant difference of serum background, antibody tilter after third immune and the weight of lyophilized extracts of induced antibody per unit of body weight between domestic rabbits and general experimental rabbits. Conclusion： It is a practicable means that domestic rabbits can partly replace general experimental rabbits as production preparation polyclonal antibody induced carriers.

关 键 词：生产性制备多克隆抗体诱发载体 家兔 普通级实验用兔 

分 类 号：R-332[医药卫生]