三草尿毒灵颗粒对大鼠肾切除致慢性肾衰模型肾功能的影响  

Effect of Sancaoniaoduling Granule on Chronic Renal Failure in Rats Induced on Kidney Removed

作　　者：肖小华[1] 徐丽瑛[1] 丁琦[1] 方铝[1] 郑国安[1] 姚闽[1] 

机构地区：[1]江西省药物研究所,江西南昌33029

出　　处：《科技广场》2012年第12期254-256,共3页Science Mosaic

基　　金：江西省科技厅支撑项目(编号:20122BBG70095);南昌市科技局支撑项目

摘　　要：目的:观察三草尿毒灵颗粒对大鼠肾切除导致慢性肾衰模型肾功能的影响。方法:将慢性肾衰模型大鼠分为5组,三草尿毒灵颗粒5.45、10.9和21.8g/kg组,尿毒清颗粒2.08g/kg组及模型组。连续灌胃给药28天,于给药后第14天和第28天测其血清Crea和BUN值,且第28天测其血清TCH值。结果:三草尿毒灵颗粒给药后28天,显著降低肾衰大鼠血清Crea和BUN值。结论:三草尿毒灵颗粒对肾切除导致慢性肾衰模型大鼠有一定的治疗作用。Object：To observe the effects of Sancaoniaoduling Granule （SCNDLG） in rats of Chronic Renal Failure induced on kidney removed. Methods：The rats of CRR model were randomly divided into 5 groups：the model group, the 5.45g/kg, 10.9g/kg, 21.8g/kg dosage groups of SCNDLG, the niaoduqing granules 2.08g/kg dosage group, and the rats＇ indexes of serum Crea, BUN etc were measured after the rats were respectively treated in SCNDLG on 14 and 28 days. Result： SCNDLG can obviously reduce rats＇ serum Crea, BUN value. Conclussion： SCNDLG has certain treatment function on rats of CRF induced on kidney removed.

关 键 词：三草尿毒灵颗粒 慢性肾衰 大鼠 

分 类 号：R-332[医药卫生]